Form 990 for tax year 2024

Totals

Total revenue

$1,888,508

Total expenses

$1,387,442

Contributions and grants received

$1,787,094

Grants paid

$491,099

Program service revenue

$19,288

Investment income

$53,281

Other revenue

$28,845

Total assets, end of year

$2,943,272

Total liabilities, end of year

$86,971

Net assets or fund balances, end of year

$2,856,301

Program services expenses (Part IX)

$1,180,179

Management and general expenses

$155,969

Fundraising expenses

$51,294

Program service expenses (Part III)

$1,180,179

Program services were 85.1% of total expenses calculated — Part IX's program-services column over total expenses, both as filed.

Line items

Every line the filer filed in Parts VIII, IX and X, as filed and in filed order. Blank columns are left out, and the lines are not forced to add up to the totals above.

Mission and programs · 2024

• Scientific Programs: Project 8p Foundation partners with top researchers and biopharma to uncover the causes of chromosome 8p disorders and improve the lives of those affected. Our work addresses urgent biological questionssuch as symptom progression, mitochondrial dysfunction, gut-brain interactions, and cellular stressto deliver actionable clinical tools for families today, while accelerating discoveries that can lead to scalable treatments for all communities affected by complex neurodevelopmental and neuromuscular conditions. Were advancing innovative technologies and accelerating therapeutic discovery by harnessing data in new ways. Our proprietary 8p Insights Portal is a growing, patient-centered resource that integrates clinical records, caregiver-reported outcomes, and biospecimen datadriving scientific breakthroughs and delivering meaningful impact for those living with chromosome 8p disorders.

  Expenses $927,478 · Grants $468,599

• Community Outreach & Conferences: Project 8p supported over 200 families with clinical tools, education, and services. We hosted a three-day Family & Science Conference, bringing together researchers, clinicians, and families to foster collaboration and accelerate progress. Through monthly roundtables and ongoing stakeholder education, we promote a team science approach while sharing the latest research, clinical insights, and lived experiences. These efforts strengthen our shared goals and ensure the voices of those affected by 8p remain central to every initiative.

  Expenses $218,505 · Grants $2,500 · Revenue $19,288

• Patient Impact (Clinics & Care): Project 8p advanced its mission to improve clinical care for individuals with chromosome 8p disorders through several key initiatives. We published the first-ever Clinical Care Guidelines for 8p, providing an evidence-informed framework to guide physicians and care teams worldwide. We also launched the Patient Navigator, a free, interactive, online tool that helps families and clinicians understand symptoms across body systemsdrawing on real-world data from our 8p Insights Portal.Additionally, we expanded our Multidisciplinary Hospital Clinic Model, supporting the development of coordinated care hubs that bring together specialists to provide comprehensive, patient-centered services. These efforts mark important strides in reducing diagnostic delays, improving care coordination, and empowering families with accessible, data-driven resources.

  Expenses $34,196 · Grants $20,000

As filed on the 2024 return.

Listed in Part VII

Compensation is as filed in Part VII: reportable pay from this organization and from related organizations, other compensation, and hours per week. The total, marked calculated, is our sum of the three dollar columns, with a blank column counted as $0; the form itself has no total. On a Form 990-EZ the columns are Part IV's instead, and on a Form 990-PF Part VIII's — compensation, contributions to benefit plans, and expense account — and the total sums those.

Grants on this return

• The Regents of the Univ of Cal

  $220,994

  Research

• University of Connecticut

  $79,923

  Research

• Yale University

  $79,647

• UC SanDiego

  $49,641

  Research

• Childrens Hospital Colorado

  $20,000

  Clinical Care

• Uplifting Athletes

  $10,000

  Research

Provenance

Return type

form_990

Tax year

2024

Filed

5 November 2025

IRS schema version

2024v5.2

Source object

202523109349301402

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