Form 990 for tax year 2025

Totals

Total revenue

$2,110,160

Total expenses

$2,141,903

Contributions and grants received

$2,102,083

Grants paid

$1,033,544

Program service revenue

$0

Investment income

$5,795

Other revenue

$2,282

Total assets, end of year

$288,737

Total liabilities, end of year

$165,646

Net assets or fund balances, end of year

$123,091

Program services expenses (Part IX)

$1,894,463

Management and general expenses

$198,603

Fundraising expenses

$48,837

Program service expenses (Part III)

$1,894,463

Program services were 88.4% of total expenses calculated — Part IX's program-services column over total expenses, both as filed.

Line items

Every line the filer filed in Parts VIII, IX and X, as filed and in filed order. Blank columns are left out, and the lines are not forced to add up to the totals above.

Mission and programs · 2025

• In 2025, the RUNX1 Research Program (RRP) continued its mission to fund research to prevent blood cancer in individuals with RUNX1 Familial Platelet Disorder (RUNX1-FPD). RRP awarded grants to investigators across leading academic medical centers, supporting research focused on disease mechanisms, clonal evolution, and blood cancer interception. Key funded programs included independent investigator grants, co-funded partnerships with Alexs Lemonade Stand Foundation, the American Cancer Society (new LEAP grant program), and support for several clinical trials (e.g. pilot study evaluating sirolimus as a preemptive intervention). RRP also continued operating its longitudinal RUNX1 Patient Data Hub, launching a centralized biospecimen bank (RUNX1 Tissue Bank), supporting patient recruitment for clinical research, and engaging the RUNX1-FPD patient and scientific community through its annual scientific conference, patient meeting, educational webinars, peer support groups, and patient-facing resources.

  Expenses $1,894,463 · Grants $1,033,544

As filed on the 2025 return. The filer continues this part on Schedule O, which is not shown here.

Listed in Part VII

Compensation is as filed in Part VII: reportable pay from this organization and from related organizations, other compensation, and hours per week. The total, marked calculated, is our sum of the three dollar columns, with a blank column counted as $0; the form itself has no total. On a Form 990-EZ the columns are Part IV's instead, and on a Form 990-PF Part VIII's — compensation, contributions to benefit plans, and expense account — and the total sums those. A Schedule J breakdown is as filed: base pay, bonus, other, deferred compensation and nontaxable benefits from this organization, with any from related organizations beside each, and the filer's own total. It is shown with the Part VII listing of the same name on the same return. The form gives no key between the two, so that pairing is ours, and is marked matched by us.

Schedule J

Part I's answers as filed. A line not listed was left unanswered; on lines 1a and 3 that means the box was not checked.

Grants on this return

• American Cancer Society Inc

  $375,000

  Research

• The University of Texas MD Anderson

  $212,517

  Research

• University of Pennsylvania

  $153,750

  Research

• Childrens Hospital of Philadelphia

  $92,107

  Research

• Oregon Health Sciences University F

  $62,296

  Research

• University of Massachussetts Medica

  $46,875

  Research

• Icahn School of Medicine at Mt Sin

  $30,000

  Research

• Cleveland Clinic Foundation

  $30,000

  Research

Provenance

Return type

form_990

Tax year

2025

Filed

8 July 2026

IRS schema version

2025v4.2

Source object

202621909349300507

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