Form 990 for tax year 2022

Totals

Total revenue

$30,503,398

Total expenses

$30,736,665

Contributions and grants received

$21,413,596

Grants paid

$0

Program service revenue

$8,615,163

Investment income

$450,437

Other revenue

$24,202

Total assets, end of year

$20,719,365

Total liabilities, end of year

$12,724,388

Net assets or fund balances, end of year

$7,994,977

Program services expenses (Part IX)

$26,191,046

Management and general expenses

$4,545,619

Fundraising expenses

$0

Program service expenses (Part III)

$26,191,046

Program services were 85.2% of total expenses calculated — Part IX's program-services column over total expenses, both as filed.

Line items

Every line the filer filed in Parts VIII, IX and X, as filed and in filed order. Blank columns are left out, and the lines are not forced to add up to the totals above.

Mission and programs · 2022

• All of Us Research Program. Principal investigators: Philip Tsao, Ph.D. and Jennifer Lee, M.D., Ph.D.The All of Us Research Program (All of Us) is a large collaborative initiative sponsored by the National Institutes of Health (NIH). All of Us includes a consortium of awardees from multiple institutions, including the Department of Veterans Affairs. All of Us is working to improve healthcare through research by building a diverse database of participant self-report information, biospecimens, and Electronic Health Records that can inform future research on a variety of health conditions. VA participation in All of Us is overseen by three Co-PIs, located at the VA Palo Alto Healthcare System and the VA Boston Healthcare System. These two institutions serve as the Coordinating Centers for all participating VA sites, providing leadership and oversight. There are currently 19 VA active recruitment sites for the program. All centralized recruitment, engagement campaigns, and compliance with program requirements is managed by the VA PIs and their respective Coordinating Center teams.

  Expenses $2,484,611

• Intestinal Lymphocyte Trafficking. Principal investigator: Eugene Butcher, M.D.The Intestinal Lymphocyte Trafficking program is a multi-year research study that started in 2007. The objectives of this program are 1) to define the molecular and genetic mechanisms that control immune cell migration to the small and large intestines, 2) to elucidate how these genes and mechanisms control infection or contribute to disease, 3) to uncover improved approaches to monitor or induce mucosal immune responses (i.e. for vaccination against infectious diseases), and 4) new therapeutic possibilities that could lead to treatments for inflammatory bowel and allergic diseases of the GI tract. During the current period, there was a discovery of a novel lung and upper GI tract trafficking program (novel chemoattractant receptor ligand pair). This discovery promises to have broad importance for upper GI (stomach), airway, and lung immunobiology. The study has yielded 25 peer reviewed manuscripts, 2 of which were in the last year. Additionally, presentations at both national and international meetings were made to share the progress of this study.

  Expenses $891,023

• Exploring Epigenetic Rejuvenation across Time and Space. Principal investigator: Thomas Rando, M.D., Ph.D. This program is a research program to discover biological pathways of aging that can be experimentally manipulated to rejuvenate cells and tissues in the body. We will use state-of-the-art technologies to engineer muscles in old mice to restore them to a more youthful state. We will evaluate the success of that process by measuring muscle functions that change with age. To the extent that we are successful in rejuvenating the aged muscle, we will evaluate the impact that has on cells and tissues throughout the body by factors secreted by muscle that travel in the blood to other tissues and organs. At the same time, we will measure biochemical changes in the cells that are known to be associated with aging. It is our hypothesis that those biochemical changes, mostly related to DNA in the nuclei of cells, will also be rejuvenated, The long term impact of these studies will be to develop new treatments for age-related diseases that affect Veterans.

  Expenses $703,221

• PAVIR is privileged to work with a large community of uniquely talented medical researchers across a broad spectrum of research areas as we fulfill our mission of advancing Veterans and public health through innovative research. The range of research activities is broad and includes special emphasis on major disease categories, all of which are prevalent in the VA's patient population. These include cardiovascular medicine, mental health, chronic inflammatory disease, stem cell/regenerative medicine, pain, sleep disorders, and many others. In addition to disease specific research, PAVIR is engaged in supporting research aimed at enhancing health care. PAVIR's research portfolio includes comparative studies in which research teams are learning which treatments are superior to others, how to augment or improve standard of care, as well as how to enhance the operation of health care. Furthermore, PAVIR is supporting educational activities, especially in areas of advancing clinical care for Veterans and fostering the professional development of our expert staff.

  Expenses $22,112,191 · Revenue $8,615,163

As filed on the 2022 return. The filer continues this part on Schedule O, which is not shown here.

Listed in Part VII

Compensation is as filed in Part VII: reportable pay from this organization and from related organizations, other compensation, and hours per week. The total, marked calculated, is our sum of the three dollar columns, with a blank column counted as $0; the form itself has no total. On a Form 990-EZ the columns are Part IV's instead, and on a Form 990-PF Part VIII's — compensation, contributions to benefit plans, and expense account — and the total sums those. A Schedule J breakdown is as filed: base pay, bonus, other, deferred compensation and nontaxable benefits from this organization, with any from related organizations beside each, and the filer's own total. It is shown with the Part VII listing of the same name on the same return. The form gives no key between the two, so that pairing is ours, and is marked matched by us.

Schedule J

Part I's answers as filed. A line not listed was left unanswered; on lines 1a and 3 that means the box was not checked.

Grants on this return

No itemized grants to organizations on this return.

Related organizations on this return

Schedule R Part II: tax-exempt organizations related to the filer by control. It does not record shared board members or money.

• VA Palo Alto Health Care System

  501(c)(1) · Teaching hospital, providing a full range of patient care services · CA

Provenance

Return type

form_990

Tax year

2022

Filed

22 May 2024

IRS schema version

2022v5.0

Source object

202421449349300447

Check it against the return as filed: the GivingTuesday Data Lake hosts a public copy of the original XML.

The source document this was parsed from is served over the API, which is where bulk and document access live.