Form 990 for tax year 2024

Totals

Total revenue

$35,854,131

Total expenses

$33,029,388

Contributions and grants received

$25,318,301

Grants paid

$0

Program service revenue

$10,144,436

Investment income

$367,884

Other revenue

$23,510

Total assets, end of year

$19,146,651

Total liabilities, end of year

$11,109,618

Net assets or fund balances, end of year

$8,037,033

Program services expenses (Part IX)

$27,791,858

Management and general expenses

$5,237,530

Fundraising expenses

$0

Program service expenses (Part III)

$27,791,858

Program services were 84.1% of total expenses calculated — Part IX's program-services column over total expenses, both as filed.

Line items

Every line the filer filed in Parts VIII, IX and X, as filed and in filed order. Blank columns are left out, and the lines are not forced to add up to the totals above.

Mission and programs · 2024

• CLINICAL TRANSLATION OF ALLOGENEIC REGENERATIVE CELL THERAPY FOR WHITE MATTER STROKE AND VASCULAR DEMENTIA. PRINCIPAL INVESTIGATOR: IRENE LORENZO LLORENTE, PH.D.STROKE IS THE LEADING CAUSE OF ADULT DISABILITY AND THE SECOND LEADING CAUSE OF DEMENTIA. WHITE MATTER STROKE (WMS) CONSTITUTES UP TO 30% OF ALL STROKE SUBTYPES AND IS A DISTINCT PROCESS FROM "LARGE ARTERY STROKE." WMS BEGINS AS SMALL INFARCTS IN DEEP PENETRATING BLOOD VESSELS IN THE BRAIN BUT PROGRESSES, ACCUMULATES, AND EXPANDS FROM PREEXISTING LESIONS INTO ADJACENT WHITE MATTER TO PRODUCE HEMIPARESIS WITH INCOMPLETE RECOVERY, GAIT ABNORMALITIES, COGNITIVE DECLINE, AND EXECUTIVE DYSFUNCTION CHARACTERISTIC OF VASCULAR DEMENTIA (VAD). UNLIKE LARGE ARTERY STROKE, WMS DOES NOT DAMAGE NEURONAL CELL BODIES BUT PRIMARILY AFFECTS AXONAL TRACTS AND GLIAL CELLS. A CELL-BASED THERAPY CAPABLE OF REPLACING LOST GLIA AND INDUCING STRUCTURAL REPAIR IN WMS/VAD HOLDS GREAT PROMISE. WE HAVE DEVELOPED A UNIQUE ALLOGENEIC HUMAN INDUCED PLURIPOTENT STEM CELL (HIPSC)-DERIVED GLIAL ENRICHED PROGENITOR (GEP) CELL THERAPY PRODUCT FOR THE TREATMENT OF WMS AND VAD. PRECLINICAL STUDIES DEMONSTRATE THAT HIPSC-GEPS TRANSPLANTED INTO THE BRAIN AFTER WMS/VAD PROMOTE MOTOR AND COGNITIVE RECOVERY THROUGH MULTIPLE MECHANISMS OF ACTION, INCLUDING AXONAL GROWTH, ASTROCYTIC MODULATION, OLIGODENDROCYTE DIFFERENTIATION, AND REMYELINATION. THIS YEAR, WE ACHIEVED A SUCCESSFUL PRE-IND MEETING WITH THE U.S. FOOD AND DRUG ADMINISTRATION (FDA) FOR GEP-101 (HIPSC-GEPS) ON FEBRUARY 26, 2026. THE DISCUSSION, INFORMED BY THE FDA'S PRELIMINARY WRITTEN RESPONSES DATED FEBRUARY 23, 2026, FOCUSED ON FOUR PRIMARY AREAS: (1) SUITABILITY OF THE HIPSC CELL LINE AND DONOR ELIGIBILITY TESTING, (2) ADEQUACY OF THE PROPOSED CLINICAL DELIVERY DEVICE AND ADDITIONAL NONCLINICAL EVALUATION NEEDS, (3) REQUIREMENTS FOR DEVICE COMPATIBILITY TESTING TO ENSURE PRODUCT QUALITY AND DOSE ACCURACY, AND (4) QUALIFICATION OF CERTAIN MANUFACTURING RAW MATERIALS, INCLUDING THE VEEV RNA REPLICON USED DURING CELL REPROGRAMMING. OVERALL, THE FDA AGREED WITH ALL POSITIONS PRESENTED, CLARIFYING EXPECTATIONS FOR MANUFACTURING CONTROLS, DEVICE USE, AND SUPPORTING NONCLINICAL DATA PRIOR TO IND SUBMISSION.FOLLOWING THE PRE-IND MEETING, WE HAVE SUBMITTED A NEW GRANT PROPOSAL TO SECURE THE NEXT ROUND OF FUNDING AND CONTINUE ADVANCING TOWARD IND APPROVAL AND FUTURE CLINICAL TRANSLATION.

  Expenses $1,310,697

• Withheld by Nonprofiteer: this text may name a private individual.

  Expenses $1,238,218

• ALL OF US RESEARCH PROGRAM. PRINCIPAL INVESTIGATORS: PHILIP TSAO, PH.D. THE ALL OF US RESEARCH PROGRAM (ALL OF US) IS A LARGE COLLABORATIVE INITIATIVE SPONSORED BY THE NATIONAL INSTITUTES OF HEALTH (NIH). ALL OF US INCLUDES A CONSORTIUM OF AWARDEES FROM MULTIPLE INSTITUTIONS, INCLUDING THE DEPARTMENT OF VETERANS AFFAIRS. ALL OF US IS WORKING TO IMPROVE HEALTHCARE THROUGH RESEARCH BY BUILDING A DIVERSE DATABASE OF PARTICIPANT SELF-REPORT INFORMATION, BIOSPECIMENS, AND ELECTRONIC HEALTH RECORDS THAT CAN INFORM FUTURE RESEARCH ON A VARIETY OF HEALTH CONDITIONS. VA PARTICIPATION IN ALL OF US IS OVERSEEN BY TWO CO-PIS, LOCATED AT THE VA PALO ALTO HEALTHCARE SYSTEM AND THE VA BOSTON HEALTHCARE SYSTEM. THESE TWO INSTITUTIONS SERVE AS THE COORDINATING CENTERS FOR VA RESPONSIBLE FOR CENTRALIZED RECRUITMENT, ENGAGEMENT CAMPAIGNS, AND COMPLIANCE WITH PROGRAM REQUIREMENTS.

  Expenses $1,062,166

• PAVIR IS PRIVILEGED TO WORK WITH A LARGE COMMUNITY OF UNIQUELY TALENTED MEDICAL RESEARCHERS ACROSS A BROAD SPECTRUM OF RESEARCH AREAS AS WE FULFILL OUR MISSION OF ADVANCING VETERANS AND PUBLIC HEALTH THROUGH INNOVATIVE RESEARCH. THE RANGE OF RESEARCH ACTIVITIES IS BROAD AND INCLUDES SPECIAL EMPHASIS ON MAJOR DISEASE CATEGORIES, ALL OF WHICH ARE PREVALENT IN THE VA'S PATIENT POPULATION. THESE INCLUDE CARDIOVASCULAR MEDICINE, MENTAL HEALTH, CHRONIC INFLAMMATORY DISEASE, STEM CELL/REGENERATIVE MEDICINE, PAIN, SLEEP DISORDERS, AND MANY OTHERS. IN ADDITION TO DISEASE SPECIFIC RESEARCH, PAVIR IS ENGAGED IN SUPPORTING RESEARCH AIMED AT ENHANCING HEALTH CARE. PAVIR'S RESEARCH PORTFOLIO INCLUDES COMPARATIVE STUDIES IN WHICH RESEARCH TEAMS ARE LEARNING WHICH TREATMENTS ARE SUPERIOR TO OTHERS, HOW TO AUGMENT OR IMPROVE STANDARD OF CARE, AS WELL AS HOW TO ENHANCE THE OPERATION OF HEALTH CARE. FURTHERMORE, PAVIR IS SUPPORTING EDUCATIONAL ACTIVITIES, ESPECIALLY IN AREAS OF ADVANCING CLINICAL CARE FOR VETERANS AND FOSTERING THE PROFESSIONAL DEVELOPMENT OF OUR EXPERT STAFF.

  Expenses $24,180,777 · Revenue $10,144,436

As filed on the 2024 return. The filer continues this part on Schedule O, which is not shown here. A text marked withheld matched a screen for wording that may name a private individual, such as an honorific or "in memory of". Most of what it withholds names no one; it is withheld so that what does is never shown.

Listed in Part VII

Compensation is as filed in Part VII: reportable pay from this organization and from related organizations, other compensation, and hours per week. The total, marked calculated, is our sum of the three dollar columns, with a blank column counted as $0; the form itself has no total. On a Form 990-EZ the columns are Part IV's instead, and on a Form 990-PF Part VIII's — compensation, contributions to benefit plans, and expense account — and the total sums those. A Schedule J breakdown is as filed: base pay, bonus, other, deferred compensation and nontaxable benefits from this organization, with any from related organizations beside each, and the filer's own total. It is shown with the Part VII listing of the same name on the same return. The form gives no key between the two, so that pairing is ours, and is marked matched by us.

Schedule J

Part I's answers as filed. A line not listed was left unanswered; on lines 1a and 3 that means the box was not checked.

Grants on this return

No itemized grants to organizations on this return.

Related organizations on this return

Schedule R Part II: tax-exempt organizations related to the filer by control. It does not record shared board members or money.

• VA PALO ALTO HEALTH CARE SYSTEM

  TEACHING HOSPITAL, PROVIDING A FULL RANGE OF PATIENT CARE SERVICES · CA

Provenance

Return type

form_990

Tax year

2024

Filed

1 June 2026

IRS schema version

2024v5.5

Source object

202621529349301322

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