Form 990 for tax year 2025

Totals

Total revenue

$1,043,829

Total expenses

$8,027,633

Contributions and grants received

$796,252

Grants paid

$3,147,137

Program service revenue

$0

Investment income

$243,884

Other revenue

$3,693

Total assets, end of year

$2,792,145

Total liabilities, end of year

$175,250

Net assets or fund balances, end of year

$2,616,895

Program services expenses (Part IX)

$7,865,622

Management and general expenses

$153,939

Fundraising expenses

$8,072

Program service expenses (Part III)

$7,865,622

Program services were 98.0% of total expenses calculated — Part IX's program-services column over total expenses, both as filed.

Line items

Every line the filer filed in Parts VIII, IX and X, as filed and in filed order. Blank columns are left out, and the lines are not forced to add up to the totals above.

Mission and programs · 2025

• ALIGN TO INNOVATE: ALIGN TO INNOVATE IS WORKING AT THE INTERSECTION OF BIOLOGY AND AI TO IMPROVE LIFE SCIENCE RESEARCH WITH PROGRAMMABLE EXPERIMENTS. WE USE AUTOMATION AS A FOCAL POINT TO ALIGN THE INCENTIVES OF RESEARCHERS WORLDWIDE TO IDENTIFY AND EXECUTE LARGE, COLLABORATIVE, DATA-INTENSIVE PROJECTS. WE ACCELERATE THESE PROJECTS BY CREATING VENUES FOR AGENDA SETTING, FACILITATING COLLABORATIONS, AND REMOVING TECHNICAL BOTTLENECKS FROM THE ECOSYSTEM. WE AIM TO MOVE THE FIELD TOWARD A NEW PARADIGM OF AUTOMATION-FIRST LIFE SCIENCE RESEARCH.ALIGN TO INNOVATE MADE SIGNIFICANT PROGRESS IN 2025. SCIENTIFIC HIGHLIGHTS INCLUDED THE 2025 PROTEIN ENGINEERING TOURNAMENT, WHICH ATTRACTED OVER 290 INTERNATIONAL TEAMS, AND THE ESTABLISHMENT OF PARTNERSHIPS WITH VARIOUS RESEARCH ORGANIZATIONS TO CREATE OPEN DATASETS IN THE BIOLOGICAL SCIENCES (E.G., MICROBIAL PHENOTYPING, PROTEIN FUNCTION, PROTEIN EXPRESSION). THE TEAM PUBLISHED RESEARCH ON A NUMBER OF TOPICS INCLUDING THE IMPACT OF DATA SCALING ON PROTEIN FUNCTION PREDICTION AND DISCUSSION PAPER ADDRESSING BOTTLENECKS IN PROTEIN EXPRESSION VIA A PROPOSED DATA COLLECTION PLATFORM.

  Expenses $6,546,600 · Grants $2,360,015

• OPEN REACTION DATABASE: THE OPEN REACTION DATABASE (ORD) IS A COLLABORATIVE, OPEN DATA INITIATIVE TO SUPPORT THE STRUCTURING AND SHARING OF ORGANIC REACTION DATA. THIS PROJECT PROVIDES CRITICAL SUPPORT TO INCREASE THE ADOPTION AND IMPACT OF ORD THROUGH PERSONNEL, DATA CURATION, TARGETED DATA GENERATION, AND REDUCING BARRIERS TO CONTRIBUTION. THIS PROJECT INCREASES AWARENESS AND ADOPTION OF ORD, LEADING TO INCREASED DATA SHARING AND CROSS-INSTITUTIONAL COLLABORATION IN BOTH DATA GENERATION AND MODEL-DRIVEN REACTION OPTIMIZATION. IN 2025, THE PROJECT COMPLETED ITS NEW CONTRIBUTIONS INTERFACE, OPENED A CALL FOR HIGH-THROUGHPUT EXPERIMENTATION (HTE) CENTER GRANTS, AND SUCCESSFULLY FUNDED THREE PROPOSALS. IT SIGNIFICANTLY EXPANDED ITS REACH BY PRESENTING AT INTERNATIONAL CONFERENCES, TRAINING PROGRAMS, AND HOSTING AN ONLINE WORKSHOP TO PLAN FOR ADDITIONAL DATA GENERATION.

  Expenses $485,488 · Grants $330,000

• PROBABILISITC PROGRAMMING: THE TEAM STRIVES TO MAKE ADVANCEMENTS IN AI THAT UNDERSTANDS THE WORLD LIKE PEOPLE DO, VIA PROBABILISTIC PROGRAMMING. TO ADVANCE THIS MISSION, THE PROBABILISTIC PROGRAMMING TEAM MAKES CONTRIBUTIONS IN THE FORM OF SOFTWARE CODE, PLANNING, AND STRATEGY TO VARIOUS OPEN-SOURCED TECHNOLOGIES, INCLUDING GENJAX AND INFERENCEQL WHICH ARE COMPONENTS OF OPENGEN. ADDITIONALLY, THE TEAM SUPPORTS THE CREATION OF GUIDES AND DOCUMENTATION IN SUPPORT OF THE OPEN-SOURCE ECOSYSTEM AND DEVELOPMENT COMMUNITY.

  Expenses $113,492

• BRAIN MAPPING: THIS PROJECT SUPPORTS INNOVATION IN THE FIELD OF BRAIN MAPPING SCIENCE AND TECHNOLOGY THROUGH GRANTS TO VISIONARY RESEARCH TEAMS WORKING AT THE CUTTING EDGE OF CONNECTOMICS AND RELATED FIELDS.

  Expenses $433,783 · Grants $433,783

• SCIENCE AND TECHNOLOGY FOR A BETTER TOMORROW: THIS PROJECT AIMS AT IMPROVING SCIENCE AND TECHNOLOGY FOR AMERICA'S FUTURE BY: (1) PROMOTING THE IMPORTANCE OF PUBLIC R&D AND HOW WE MOVE IT FORWARD AGAIN; (2) DEVELOPING PATHWAYS TO ACHIEVE BIGGER, BETTER AMBITIONS FOR AI, SUCH AS USING AI TO CREATE BETTER DRUGS FASTER, CLOSE EDUCATIONAL GAPS FOR OUR KIDS, AND CRAFT BETTER WEATHER FORECASTS; AND (3) DEVELOPING PERSUASIVE STORIES OF THE AMERICAN INNOVATIONS THAT HAVE SHAPED AND CONTINUE TO SHAPE OUR LIVES.

  Expenses $183,918

• SILVER LININGS INSTITUTE: THE MISSION OF THIS PROJECT IS TO UNLOCK FUNDING AND TALENT TO CATALYZE PROGRESS IN AGING SCIENCE. BY RAISING THE PUBLIC'S EXPECTATIONS OF WHAT IS POSSIBLE IN AGING SCIENCE AND MARRYING THIS NEW NARRATIVE WITH POLICY SOLUTIONISM, THE TEAM HOPES TO ACCELERATE FUNDING FOR AGING R&D AND BOLSTER AMERICA'S NATIONAL COMPETITIVENESS WHILE REDUCING FAST-RISING HEALTH COSTS.

  Expenses $64,000

• NUCLEAR ELECTRIC PROPULSION: THIS PROJECT SUPPORTS THE ADVANCEMENT OF NUCLEAR ELECTRIC PROPULSION (NEP) TECHNOLOGY FOR SPACE TRAVEL BY INCREASING COLLABORATION BETWEEN VARIOUS STAKEHOLDERS IN THE SPACE (E.G., GOVERNMENT INSTITUTIONS, UNIVERSITIES, PRIVATE AND PUBLIC RESEARCH ORGANIZATIONS).

  Expenses $23,339 · Grants $23,339

• EVOLUTIONARY COSMOLOGY RESEARCH: THIS PROJECT FOCUSES ON ADVANCING AND TESTING THE HYPOTHESES RELATED TO THREE-STAGE COSMOLOGICAL NATURAL SELECTION, AND BLOWTORCH THEORY, WHICH EXPLORES JET-DRIVEN STRUCTURE FORMATION VIA ORIGINAL THEORY PAPERS, TESTABLE PREDICTIONS, COLLABORATIVE SIMULATIONS, BIANNUAL WORKSHOPS, AND PUBLIC OUTREACH.

  Expenses $15,002

As filed on the 2025 return. The filer continues this part on Schedule O, which is not shown here.

Listed in Part VII

Compensation is as filed in Part VII: reportable pay from this organization and from related organizations, other compensation, and hours per week. The total, marked calculated, is our sum of the three dollar columns, with a blank column counted as $0; the form itself has no total. On a Form 990-EZ the columns are Part IV's instead, and on a Form 990-PF Part VIII's — compensation, contributions to benefit plans, and expense account — and the total sums those. A Schedule J breakdown is as filed: base pay, bonus, other, deferred compensation and nontaxable benefits from this organization, with any from related organizations beside each, and the filer's own total. It is shown with the Part VII listing of the same name on the same return. The form gives no key between the two, so that pairing is ours, and is marked matched by us.

Schedule J

Part I's answers as filed. A line not listed was left unanswered; on lines 1a and 3 that means the box was not checked.

Grants on this return

• THE ALIGN FOUNDATION

  $2,300,000

  GENERAL SUPPORT

• CONVERGENT RESEARCH INC

  $433,783

  GENERAL SUPPORT

• CALIFORNIA INSTITUTE OF TECHNOLOGY

  $110,000

  GENERAL SUPPORT

• UNIVERSITY OF DELAWARE

  $110,000

  GENERAL SUPPORT

• INSTITUTE FOR SPACE SCIENCE AND DEVELOPMENT

  $23,338

  GENERAL SUPPORT

Provenance

Return type

form_990

Tax year

2025

Filed

13 April 2026

IRS schema version

2025v4.1

Source object

202621039349300817

Check it against the return as filed: the GivingTuesday Data Lake hosts a public copy of the original XML.

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