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Nonprofiteer
← CANCER PREVENTION INITIATIVE INC

Form 990 for tax year 2025

Filed by CANCER PREVENTION INITIATIVE INC.

Totals

Total revenue
$778,663
Total expenses
$856,539
Contributions and grants received
$701,483
Grants paid
$725,000
Program service revenue
$0
Investment income
$77,180
Other revenue
$0
Total assets, end of year
$1,927,394
Total liabilities, end of year
$360,200
Net assets or fund balances, end of year
$1,567,194
Program services expenses (Part IX)
$731,546
Management and general expenses
$28,204
Fundraising expenses
$96,789
Program service expenses (Part III)
$731,546

Program services were 85.4% of total expenses calculated — Part IX's program-services column over total expenses, both as filed.

Line items

Every line the filer filed in Parts VIII, IX and X, as filed and in filed order. Blank columns are left out, and the lines are not forced to add up to the totals above.

Revenue

Part VIII, the statement of revenue.

  • 1a · Federated campaigns

    $0

  • 1b · Membership dues

    $0

  • 1c · Fundraising events

    $0

  • 1d · Related organizations

    $0

  • 1e · Government grants (contributions)

    $0

  • 1f · All other contributions, gifts and grants

    $701,483

  • 1g · Noncash contributions included above

    $0

  • 3 · Investment income

    total $77,180 · related or exempt $0 · unrelated business $0 · excluded $77,180

  • 4 · Income from investment of tax-exempt bond proceeds

    total $0 · related or exempt $0 · unrelated business $0 · excluded $0

  • 5 · Royalties

    total $0 · related or exempt $0 · unrelated business $0 · excluded $0

  • 6c · Rental income or loss

    real property $0 · personal property $0

  • 7c · Gain or loss

    securities $0 · other assets $0

  • 8a · Fundraising events: contributions included on line 1c

    $0

  • 11e · Other revenue, total

    $0

Functional expenses

Part IX, the statement of functional expenses.

  • 1 · Grants to domestic organizations and governments

    total $725,000 · program services $725,000

  • 2 · Grants to domestic individuals

    total $0 · program services $0

  • 3 · Grants to foreign organizations and individuals

    total $0 · program services $0

  • 4 · Benefits paid to or for members

    total $0 · program services $0

  • 5 · Compensation of officers, directors and key employees

    total $0 · program services $0 · management and general $0 · fundraising $0

  • 6 · Compensation of disqualified persons

    total $0 · program services $0 · management and general $0 · fundraising $0

  • 7 · Other salaries and wages

    total $0 · program services $0 · management and general $0 · fundraising $0

  • 8 · Pension plan contributions

    total $0 · program services $0 · management and general $0 · fundraising $0

  • 9 · Other employee benefits

    total $0 · program services $0 · management and general $0 · fundraising $0

  • 10 · Payroll taxes

    total $0 · program services $0 · management and general $0 · fundraising $0

  • 11a · Fees: management

    total $0 · program services $0 · management and general $0 · fundraising $0

  • 11b · Fees: legal

    total $0 · program services $0 · management and general $0 · fundraising $0

  • 11c · Fees: accounting

    total $12,310 · program services $0 · management and general $12,310 · fundraising $0

  • 11d · Fees: lobbying

    total $0 · program services $0 · management and general $0 · fundraising $0

  • 11e · Fees: professional fundraising services

    total $90,000 · fundraising $90,000

  • 11f · Fees: investment management

    total $0 · program services $0 · management and general $0 · fundraising $0

  • 11g · Fees: other

    total $12,250 · program services $0 · management and general $6,125 · fundraising $6,125

  • 12 · Advertising and promotion

    total $479 · program services $0 · management and general $0 · fundraising $479

  • 13 · Office expenses

    total $2,965 · program services $0 · management and general $2,780 · fundraising $185

  • 14 · Information technology

    total $6,087 · program services $6,087

  • 19 · Conferences, conventions and meetings

    total $459 · program services $459

  • 22 · Depreciation, depletion and amortization

    total $1,600 · management and general $1,600

  • 23 · Insurance

    total $2,832 · management and general $2,832

  • 24a · Other expenses: Dues and Subscriptions

    total $756 · program services $0 · management and general $756 · fundraising $0

  • 24b · Other expenses: Fees and Licenses

    total $1,826 · program services $0 · management and general $1,826 · fundraising $0

  • 24c · Other expenses: Bank Charges

    total -$25 · program services $0 · management and general -$25 · fundraising $0

Balance sheet

Part X, book values.

  • 1 · Cash, non-interest-bearing

    beginning of year $833 · end of year $52,657

  • 2 · Savings and temporary cash investments

    beginning of year $4,500 · end of year $11,000

  • 3 · Pledges and grants receivable

    beginning of year $0 · end of year $0

  • 4 · Accounts receivable

    beginning of year $0 · end of year $0

  • 5 · Loans and receivables from officers and key people

    beginning of year $0 · end of year $0

  • 6 · Loans and receivables from disqualified persons

    beginning of year $0 · end of year $0

  • 7 · Other notes and loans receivable

    beginning of year $0 · end of year $0

  • 8 · Inventories for sale or use

    beginning of year $0 · end of year $0

  • 9 · Prepaid expenses and deferred charges

    beginning of year $1,063 · end of year $8,104

  • 11 · Investments: publicly traded securities

    beginning of year $2,217,253 · end of year $1,855,633

  • 14 · Intangible assets

    beginning of year $1,600 · end of year $0

  • 17 · Accounts payable and accrued expenses

    beginning of year $0 · end of year $10,000

  • 18 · Grants payable

    beginning of year $580,000 · end of year $350,000

  • 19 · Deferred revenue

    beginning of year $0

  • 20 · Tax-exempt bond liabilities

    beginning of year $0

  • 21 · Escrow or custodial account liability

    beginning of year $0

  • 22 · Loans and payables to officers and key people

    beginning of year $0

  • 23 · Secured mortgages and notes payable

    beginning of year $0

  • 24 · Unsecured notes and loans payable

    beginning of year $0

  • 25 · Other liabilities

    beginning of year $179 · end of year $200

  • 27 · Net assets without donor restrictions

    beginning of year $328,570 · end of year $535,694

  • 28 · Net assets with donor restrictions

    beginning of year $1,316,500 · end of year $1,031,500

Mission and programs · 2025

Mission

Cancer Prevention Initiative, Inc. (CPI) is a nonprofit corporation whose mission is to accelerate the discovery and development of new medicines that prevent cancer. CPI uses its research, medical and pharmaceutical expertise to invest in first-rate science that will discover new medical methods for preventing cancer. Our strategy is to support research on prevention of inherited cancers as a path towards elimination of all cancers. CPI acts as a facilitator to ensure that good ideas can find sufficient funding to turn them into therapeutic solutions such as drugs or vaccines to prevent cancer. CPI provides financial support, guidance and expertise throughout the research and development process to help researchers use the resources (donations) for the highest possible impact.

Activities or mission (Part I)

Cancer Prevention Initiative, Inc. (CPI) is a nonprofit corporation whose mission is to accelerate the discovery and development of new medicines that prevent cancer. We support research on prevention of inherited cancers as a path toward the elimination of all cancers.

  • In 2025, Cancer Prevention Initiative (CPI) supported five active projects studying therapeutic prevention of inherited cancer. Four of the projects study BRCA1/2 mutated cancers and one project studies Lynch Syndrome. Two of the projects, one at Cleveland Clinic and one at Dana-Farber, are developing immunoprevention strategies to combat BRCA mutant breast cancer. Another immunoprevention project at MD Anderson is developing vaccines to prevent Lynch syndrome-associated colorectal cancer. The project at Harvard/Beth Israel Deaconess Medical center is identifying risk factors in the fallopian tube that gives rise to ovarian cancer in BRCA1 mutation carriers. This work would help develop tests and assays for early detection and risk assessment of ovarian cancer. At Memorial Sloan Kettering Cancer Center, CPI supports a project to prevent Loss of Heterozygosity (LoH) of BRCA genes, a major driver in cancer initiation, and thereby prevent the development of cancer.

    Expenses $731,546 · Grants $725,000

  • Education and engagement programs: As we move closer to our goal of eradicating all cancers through preventative medicines, we believe that raising awareness about inherited cancer syndromes will inspire more individuals to take proactive, life-saving preventive measures. One of the goals is to enhance the scientific reach of the organization and raise awareness on cancer prevention to a broader audience of patients, advocates and donors. Updates on scientific and medical research advances, recent clinical trials, and interviews with experts in cancer prevention are published on web-based platforms.

As filed on the 2025 return.

Listed in Part VII

  • Theodora Ross

    President & Chief Scientific Officer; Trustee

    Total calculated
    $0
    Hours/week
    5

  • Howard Janzen

    Board Chair; Secretary; Trustee

    Total calculated
    $0
    Hours/week
    5

  • Jan Livingston-Mokhtari

    Trustee

    Total calculated
    $0
    Hours/week
    1

  • Douglas Hager

    Trustee, Sr. Vice President, Project Management and Operations

    Total calculated
    $0
    Hours/week
    10

  • Joi Morris

    Treasurer, Trustee

    Total calculated
    $0
    Hours/week
    6

  • Kirk Patrick

    Secretary, Trustee

    Total calculated
    $0
    Hours/week
    0.5

Compensation is as filed in Part VII: reportable pay from this organization and from related organizations, other compensation, and hours per week. The total, marked calculated, is our sum of the three dollar columns, with a blank column counted as $0; the form itself has no total. On a Form 990-EZ the columns are Part IV's instead, and on a Form 990-PF Part VIII's — compensation, contributions to benefit plans, and expense account — and the total sums those.

Grants on this return

  • University of Texas MD Anderson Cancer Center

    $450,000

    The purpose of the Grant is for the Principal Investigator to carry out the research to develop immune interventions that could reduce the risk of Lynch Syndrome (LS)-related cancers. The goals of the project are to develop vaccines and test their potential to prevent colorectal cancer in a preclinical model of LS and to explore the colonic immune microenvironment.

  • Memorial Sloan Kettering Cancer Center

    $150,000

    This project to identify factors that influence the Loss of Heterozygosity (LOH) was initially funded in 2019. Based on the significant progress made in the project, the project was granted additional funding to continue to phase 2 in 2021 and phase 3 in 2024-2025. During phase 3, they will study allele loss under BRCA wildtype and heterozygous conditions. These studies will provide a comparative mechanistic understanding of LOH at BRCA under normal and carrier conditions. This mechanistic understanding will facilitate development of strategies to prevent LOH and thereby prevent cancer development in high-risk individuals.

  • University of Texas Southwestern Medical Center

    $125,000

    Scientific and administrative oversight of all Cancer Prevention Initiative programs.

Provenance

Return type
form_990
Tax year
2025
Filed
6 May 2026
IRS schema version
2025v4.0
Source object
202601329349305575

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