- Revenue 2024
- $13,409,685
- Expenses 2024
- $28,738,257
Program services were 91.3% of total expenses calculated — Part IX's program-services column over total expenses, both as filed.
As filed
- Subsection
- 03
- Classification
- 1000
- Street
- 101 ROGERS ST
These codes are the IRS's own and are shown exactly as filed. What each one means is in the Business Master File documentation (opens in a new tab).
Mission and programs · 2024
Mission
BREAK THROUGH CANCER IS A FOUNDATION DEDICATED TO SUPPORTING TRANSLATIONAL RESEARCH IN THE MOST DIFFICULT TO TREAT CANCERS. OUR PARTNER ORGANIZATIONS ARE AMONG THE TOP CANCER RESEARCH CENTERS AND TOGETHER, REPRESENT SOME OF THE MOST BRILLIANT, CREATIVE MINDS IN THE COUNTRY. WE BELIEVE BREAK THROUGH CANCER IS THE BEGINNING OF A SCIENTIFIC MOVEMENT THAT ACCEPTS NOTHING LESS THAN MULTI-INSTITUTIONAL COLLABORATION IN PATIENT CENTRIC CANCER RESEARCH. THE FOUNDATION WILL WORK CLOSELY WITH TEAMS OF SCIENTISTS, ENGINEERS, AND CLINICAL RESEARCHERS TO FOCUS ON DIAGNOSING, TREATING, AND IDEALLY CURING SOME OF THE MOST INTRACTABLE FORMS OF CANCER. WHILE MANY PATIENTS HAVE BENEFITED FROM ADVANCES IN RESEARCH AND TECHNOLOGY, THERE ARE TOO MANY WHO HAVE BEEN LEFT BEHIND. THERE ARE TOO MANY CANCERS WHERE THE NEEDLE REMAINS UNMOVED. BREAK THROUGH CANCER IS COMMITTED TO MAKING HEADWAY IN THESE EXTREMELY COMPLEX, CHALLENGING DISEASES, AND COMMITTED TO FINDING HOPE FOR PATIENTS AND THEIR FAMILIES.
Activities or mission (Part I)
BREAK THROUGH CANCER IS A FOUNDATION DEDICATED TO SUPPORTING TRANSLATIONAL RESEARCH IN THE MOST DIFFICULT TO TREAT CANCERS. OUR PARTNER ORGANIZATIONS ARE AMONG THE TOP CANCER RESEARCH CENTERS AND TOGETHER, REPRESENT SOME OF THE MOST BRILLIANT, CREATIVE MINDS IN THE COUNTRY. WE BELIEVE BREAK THROUGH CANCER IS THE BEGINNING OF A SCIENTIFIC MOVEMENT THAT ACCEPTS NOTHING LESS THAN MULTI-INSTITUTIONAL COLLABORATION IN PATIENT CENTRIC CANCER RESEARCH. THE FOUNDATION WILL WORK CLOSELY WITH TEAMS OF SCIENTISTS, ENGINEERS, AND CLINICAL RESEARCHERS TO FOCUS ON DIAGNOSING, TREATING, AND IDEALLY CURING SOME OF THE MOST INTRACTABLE FORMS OF CANCER. WHILE MANY PATIENTS HAVE BENEFITED FROM ADVANCES IN RESEARCH AND TECHNOLOGY, THERE ARE FAR TOO MANY WHO HAVE BEEN LEFT BEHIND. THERE ARE TOO MANY CANCERS WHERE THE NEEDLE REMAINS UNMOVED. BREAK THROUGH CANCER IS COMMITTED TO MAKING HEADWAY IN THESE EXTREMELY COMPLEX, CHALLENGING DISEASES, AND COMMITTED TO FINDING HOPE FOR PATIENTS AND THEIR FAMILIES.
-
PROVIDES FUNDING TO TEAMS OF RESEARCHERS FROM THE FIVE TOP CANCER RESEARCH CENTERS: DANA-FARBER CANCER INSTITUTE, THE SIDNEY KIMMEL COMPREHENSIVE CANCER CENTER AT JOHN HOPKINS, MASSACHUSETTS INSTITUTE OF TECHNOLOGY'S KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH, THE UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER, AND MEMORIAL SLOAN KETTERING CANCER CENTER IN ORDER TO HELP INTERCEPT CANCER EARLY, DEVELOP MORE EFFECTIVE TREATMENTS, AND ACCELERATE CURES FOR SOME OF THE DEADLIEST CANCERS.
Expenses $26,250,079 · Revenue $13,409,685
As filed on the 2024 return. The filer continues this part on Schedule O, which is not shown here.
Officers and directors · 2024
As listed in Part VII of the 2024 return, in the order the filer printed them. Each return names its own; this is not a roster the organization keeps with us.
-
BILL GOODWIN
DIRECTOR
- Total calculated
- $0
- Hours/week
- 1
-
ALICE GOODWIN
DIRECTOR
- Total calculated
- $0
- Hours/week
- 1
-
JOHN SHERMAN
DIRECTOR
- Total calculated
- $0
- Hours/week
- 1
-
SUSAN HOCKFIELD
DIRECTOR
- Total calculated
- $0
- Hours/week
- 1
-
GIULIO DRAETTA
DIRECTOR
- Total calculated
- $0
- Hours/week
- 1
-
DAVID JAFFRAY
DIRECTOR
- Total calculated
- $0
- Hours/week
- 1
-
BILL NELSON
CHAIRMAN
- Total calculated
- $0
- Hours/week
- 1
-
DAVID SCHEINBERG
DIRECTOR
- Total calculated
- $0
- Hours/week
- 1
-
MATT VANDER HEIDEN
DIRECTOR
- Total calculated
- $0
- Hours/week
- 1
-
LISA DEANGELIS
DIRECTOR
- Total calculated
- $0
- Hours/week
- 1
-
BENJAMIN EBERT
DIRECTOR
- Total calculated
- $0
- Hours/week
- 1
-
BILL HAHN
DIRECTOR
- Total calculated
- $0
- Hours/week
- 1
-
ELIZABETH JAFFEE
DIRECTOR
- Total calculated
- $0
- Hours/week
- 1
-
TYLER JACKS
PRESIDENT/DIRECTOR
- Total calculated
- $262,500
- From this org
- $250,000
- From related orgs
- $0
- Other
- $12,500
- Hours/week
- 20
Schedule J breakdown matched by us
- Base
- $250,000
- Bonus
- $0
- Other
- $0
- Deferred
- $12,500
- Nontaxable benefits
- $0
- Filer's total
- $262,500
-
LISA SCHWARZ
COO/CPO/SECRETARY
- Total calculated
- $319,764
- From this org
- $268,629
- From related orgs
- $0
- Other
- $51,135
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $268,629
- Bonus
- $0
- Other
- $0
- Deferred
- $13,404
- Nontaxable benefits
- $37,731
- Filer's total
- $319,764
-
WILLIAM HULME
CFO/TREASURER
- Total calculated
- $224,827
- From this org
- $213,080
- From related orgs
- $0
- Other
- $11,747
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $213,080
- Bonus
- $0
- Other
- $0
- Deferred
- $10,582
- Nontaxable benefits
- $1,165
- Filer's total
- $224,827
-
JESSE BOEHM
CHIEF SCIENCE OFFICER
- Total calculated
- $303,514
- From this org
- $254,285
- From related orgs
- $0
- Other
- $49,229
- Hours/week
- 32
Schedule J breakdown matched by us
- Base
- $254,285
- Bonus
- $0
- Other
- $0
- Deferred
- $12,687
- Nontaxable benefits
- $36,542
- Filer's total
- $303,514
-
KARI MCHUGH
CHIEF COMMUNICATIONS OFFICER
- Total calculated
- $245,080
- From this org
- $211,962
- From related orgs
- $0
- Other
- $33,118
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $211,962
- Bonus
- $0
- Other
- $0
- Deferred
- $10,565
- Nontaxable benefits
- $22,553
- Filer's total
- $245,080
-
MICHEAL NOBLE
CHIEF DATA SCIENCE OFFICER
- Total calculated
- $346,224
- From this org
- $303,386
- From related orgs
- $0
- Other
- $42,838
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $303,386
- Bonus
- $0
- Other
- $0
- Deferred
- $15,142
- Nontaxable benefits
- $27,696
- Filer's total
- $346,224
-
TERENCE MCGOWAN
MANAGING DIRECTOR OF DEVELOPMENT
- Total calculated
- $239,739
- From this org
- $224,788
- From related orgs
- $0
- Other
- $14,951
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $224,788
- Bonus
- $0
- Other
- $0
- Deferred
- $11,162
- Nontaxable benefits
- $3,789
- Filer's total
- $239,739
-
CHRISTINA SCHULTZ
SR. DIRECTOR OF SCIENCE PROGRAMS
- Total calculated
- $215,996
- From this org
- $202,116
- From related orgs
- $0
- Other
- $13,880
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $201,116
- Bonus
- $1,000
- Other
- $0
- Deferred
- $9,975
- Nontaxable benefits
- $3,905
- Filer's total
- $215,996
-
JONATHAN GRABENSTATTER
DIRECTOR, STRATEGIC ALLIANCES
- Total calculated
- $212,329
- From this org
- $175,692
- From related orgs
- $0
- Other
- $36,637
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $174,692
- Bonus
- $1,000
- Other
- $0
- Deferred
- $0
- Nontaxable benefits
- $36,637
- Filer's total
- $212,329
-
HENRY DEWHURST
PRINCIPAL DATA SCIENCE ENGINEER
- Total calculated
- $185,162
- From this org
- $141,569
- From related orgs
- $0
- Other
- $43,593
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $140,569
- Bonus
- $1,000
- Other
- $0
- Deferred
- $6,951
- Nontaxable benefits
- $36,642
- Filer's total
- $185,162
-
LUCIAN DE WAAL
SCENTIFIC PORTFOLIO MANAGER
- Total calculated
- $166,687
- From this org
- $132,975
- From related orgs
- $0
- Other
- $33,712
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $131,975
- Bonus
- $1,000
- Other
- $0
- Deferred
- $6,461
- Nontaxable benefits
- $27,251
- Filer's total
- $166,687
-
JOHN OKELLO
SCENTIFIC PORTFOLIO MANAGER
- Total calculated
- $154,595
- From this org
- $124,081
- From related orgs
- $0
- Other
- $30,514
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $123,081
- Bonus
- $1,000
- Other
- $0
- Deferred
- $6,058
- Nontaxable benefits
- $24,456
- Filer's total
- $154,595
The first 25 listed. Compensation is as filed in Part VII: reportable pay from this organization and from related organizations, other compensation, and hours per week. The total, marked calculated, is our sum of the three dollar columns, with a blank column counted as $0; the form itself has no total. On a Form 990-EZ the columns are Part IV's instead, and on a Form 990-PF Part VIII's — compensation, contributions to benefit plans, and expense account — and the total sums those. A Schedule J breakdown is as filed: base pay, bonus, other, deferred compensation and nontaxable benefits from this organization, with any from related organizations beside each, and the filer's own total. It is shown with the Part VII listing of the same name on the same return. The form gives no key between the two, so that pairing is ours, and is marked matched by us. Earlier years are each on their own filing page.
Filings
-
2024
- Revenue
- $13,409,685
- Expenses
- $28,738,257
- Contributions
- $13,402,699
- Grants paid
- $0
-
2023
- Revenue
- $2,386,142
- Expenses
- $32,184,501
- Contributions
- $2,380,369
- Grants paid
- $0
-
2022
- Revenue
- $27,161,244
- Expenses
- $24,291,674
- Contributions
- $27,158,045
- Grants paid
- $0
The four totals the IRS asks for on Part I of the Form 990, as filed. A dash means the figure was not present on the return — not that it was zero.
Other returns filed
-
2021 · 990
- Revenue
- $99,715,148
- Expenses
- $1,511,418
- Assets (EOY)
- $98,272,406
-
2020 · 990
- Revenue
- $267,646
- Expenses
- $267,646
- Assets (EOY)
- $0
Nonprofiteer parses Forms 990, 990-EZ and 990-PF, in a window of recent tax years. These returns are recorded from the IRS e-file index, so their figures were extracted by that index rather than read from the return here — treat them as a different source from the filings above, not as more of the same record. A dash means the index carries no figure; Form 990-T listings carry none at all.
Grants made
No itemized grants to organizations. Schedule I is filed only by organizations that granted more than $5,000 to a recipient, so most filers have none.
Grants received
-
2023 SUPPORT FOR MULTI-INSTITUTIONAL RESEARCH IN CANCER INDICATIONS
-
2024 SUPPORT FOR MULTI-INSTITUTIONAL RESEARCH IN CANCER INDICATIONS
-
2022 SUPPORT FOR MULTI-INSTITUTIONAL RESEARCH IN CANCER INDICATIONS
-
FIDELITY INVESTMENTS CHARITABLE GIFT FUND
$1,001,950
2024 For grant recipient's exempt purposes
-
$500,000
2024 RESEARCH AGREEMENT
-
$500,000
2025 RESEARCH AGREEMENT
-
$30,000
2022 HEALTH AND WELLNESS
-
2022 For grant recipient's exempt purposes
-
$15,000
2023 HEALTH AND WELLNESS
-
$10,000
2024 FOR RECIPIENT'S EXEMPT PURPOSE
The 10 largest by cash amount. The API serves every itemized grant.
Other IRS files
Auto-Revocation List
Not listed. The IRS publishes this list for organizations whose exemption was automatically revoked for failing to file for three consecutive years.
Publication 78
Listed as of 13 October 2026, under deductibility PC.
These are two separate IRS files on two separate schedules, shown as published and not reconciled with each other. Neither is a statement about whether a contribution is deductible today: 19,245 organizations appear in Publication 78 while the IRS's own revocation file lists them as currently revoked, more than half of those revoked before 2019. Absence from Publication 78 is evidence of nothing, and presence is not evidence either. Verify current status with the IRS before relying on it.
What this page reflects
The registration facts above come from the IRS Business Master File published 13 October 2026 and read 23 October 2026, for every organization at once. Returns through tax year 2024, the newest we have parsed for this organization.