SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE

As filed

Subsection

03

NTEE code

G30

Classification

2800

Street

3525 JOHN HOPKINS CT STE 200

These codes are the IRS's own and are shown exactly as filed. What each one means is in the Business Master File documentation (opens in a new tab).

Other organizations at this address

1 other organization in the IRS Business Master File lists the same street address. matched by us

This address is a suite or unit (STE 200). Organizations that share one are often clients of the same office-services firm, accountant or registered agent rather than related to each other.

We match the street line and ZIP code as the IRS gives them, ignoring case and outer spaces and nothing else, so "AVE" and "AVENUE" count as different streets and this list can miss some. A shared address can mean related organizations or a shared office, but it can also be a registered agent, a mail drop or a service provider holding mail for unrelated clients. It is not, by itself, evidence that two organizations are connected.

• BALLAD RESEARCH INSTITUTE

  EIN 46-3097024

Mission and programs · 2024

• HIV-associated neurological disease: Currently, more than half of HIV patients have HIV-associated neurocognitive disorder (HAND). Although drugs to control HIV infection have been instrumental in preventing progression to AIDS, they do not protect from HAND, which is now on the rise as this patient population is aging. SDBRI scientists working on HAND have discovered a biological process that we believe is involved in accelerating the aging process in people with HIV, increasing their risk of dementia. SDBRI scientists are now focused on designing and testing strategies to stop that biological process for the purpose of preventing the onset of dementia. In addition, drug abuse, particularly methamphetamine, increases the number of cells that HIV likes to infect in the central nervous system, increasing the HIV reservoir and aggravating inflammation. SDBRI research is focused on how methamphetamine encourages cells in the brain to attract and provide a home for HIV infection. This information will then be used to design therapies to stop HIV from infecting cells in the brain. A Senior Staff Scientist from France and a Staff Scientist. From Malaysia received salary and benefits while being trained at SDBRI in a variety of cellular immunology and sterile techniques to better understand the effect of methamphetamine on HIV infection in experimental models.

  Expenses $2,155,607 · Revenue $74,002

• Withheld by Nonprofiteer: this text may name a private individual.

  Expenses $1,558,973

• Cancer:A major question in cancer treatment remains, why do some people respond to treatment and others dont. Finding new ways to detect and treat cancer could potentially lead to cures that are currently unavailable to the majority of patients. At SDBRI scientists are developing a new technology to identify previously unidentifiable cancer-specific targets that might be used to design novel cancer fighting drugs. A Postdoctoral Fellow from Japan received salary and benefits while being trained at SDBRI in a variety of cellular immunology and sterile techniques to better understand techniques to help diagnose and treat cancer.DNA replication and disease DNA replicates in a highly organized way in healthy cells. However, in unhealthy cells, DNA replication is mis-regulated. SDBRI scientists are working to understand how DNA replication is mis-regulated in human disease in the hopes of finding new therapeutic approaches to preventing and reversing diseases such as cancer.Cells in our bodies eat internal parts of themselves to maintain their own health. This process, known as autophagy (spokeno-to-foh-jee), is essential for removing toxic material that causes diseases such as neurodegeneration and cancer. In autophagy, components inside cells are placed in a trash bag called the autophagosome which looks like a balloon. The autophagosome then fuses with the cells incinerator to decompose the transported toxic material. Scientists at SDBRI are working to understand how these complicated events are controlled in the hopes that interventions in these pathways might lead to novel treatments for disease.

  Expenses $1,423,018

• HIV/AIDS: The World Health Organization recently estimated that 36.7 million people live with HIV/AIDS worldwide with 1 million HIV-related deaths every year. New infections are estimated at an alarming 1.8 million worldwide. Developing a successful HIV vaccine is a major global health initiative. Research at SDBRI is focused on introducing novel designs to create an HIV vaccine that more people respond to. The SDBRI strategy of using HIV virus-like particles (VLPs) and mRNA as a vaccine platform is showing great promise. In addition, SDBRI scientists have designed ways to identify factors that help the immune system respond to HIV vaccines. This is very important because it might allow us to enhance the vaccine making it work in more people. SDBRI continues to participate in a multi-organization HIV vaccine research program. Our investigators work with scientists across the U.S. and in several foreign countries, including The Netherlands and Malaysia. A Staff Scientist from Malaysia received salary & benefits while being trained at SDBRI in a variety of cellular, molecular and biochemical techniques to better understand the human response to vaccines.

  Expenses $1,160,489

• Parkinsons Disease:Parkinsons disease (PD) is a neurodegenerative disorder that affects approximately 1% of the population over the age of 60. In the U.S. alone about 50,000 new cases are reported annually. It is believed that PD is caused by a combination of environmental and genetic factors. Scientists at SDBRI are working on the idea that allergic reactions represent an important environmental component in making people more susceptible to the development of PD. If this is true, components of the allergic response might be used as novel therapeutic targets to prevent PD or reduce its progression.

  Expenses $1,113,358

• Allergy and Asthma Severe asthma is a rising health problem affecting millions of Americans with no current curative solutions. It is characterized by persistent airway inflammation and corticosteroid resistance. The study conducted at SDBRI aims to understand why some patients do not respond to standard asthma therapeutics, focusing on an immune cell type discovered by SDBRI investigators. These studies will teach us how pathogenic cells are generated in asthma and how these pathogenic cells interact with other immune cells subsets to curtail allergic airway inflammation and asthma. Findings could establish improved predictors for patient stratification, leading to more targeted therapies for asthma patients.

  Expenses $637,878

• SYSTEMATIC LUPUS ERYTHEMATOSUS (SLE):SLE is caused by the immune system as it attacks the bodys tissue. Although there is a clear genetic predisposition to SLE, environmental factors also contribute to disease development. Ongoing work at SDBRI is focused on how genetic factors combine with virus infection and silica inhalation to cause SLE. It is hoped that understanding how the combination of these elements contribute to the development of SLE will provide information that can be used to develop therapies that block these interactions and the resulting disease.

  Expenses $613,151

As filed on the 2024 return. The filer continues this part on Schedule O, which is not shown here. A text marked withheld matched a screen for wording that may name a private individual, such as an honorific or "in memory of". Most of what it withholds names no one; it is withheld so that what does is never shown.

Officers and directors · 2024

As listed in Part VII of the 2024 return, in the order the filer printed them. Each return names its own; this is not a roster the organization keeps with us.

Compensation is as filed in Part VII: reportable pay from this organization and from related organizations, other compensation, and hours per week. The total, marked calculated, is our sum of the three dollar columns, with a blank column counted as $0; the form itself has no total. On a Form 990-EZ the columns are Part IV's instead, and on a Form 990-PF Part VIII's — compensation, contributions to benefit plans, and expense account — and the total sums those. A Schedule J breakdown is as filed: base pay, bonus, other, deferred compensation and nontaxable benefits from this organization, with any from related organizations beside each, and the filer's own total. It is shown with the Part VII listing of the same name on the same return. The form gives no key between the two, so that pairing is ours, and is marked matched by us. Earlier years are each on their own filing page.

Filings

• 2024

  Revenue

  $8,921,973

  Expenses

  $9,347,122

  Contributions

  $8,798,203

  Grants paid

  $0

• 2023

  Revenue

  $7,629,808

  Expenses

  $8,239,939

  Contributions

  $7,543,672

  Grants paid

  $0

• 2022

  Revenue

  $6,229,349

  Expenses

  $7,394,007

  Contributions

  $6,089,666

  Grants paid

  $0

The four totals the IRS asks for on Part I of the Form 990, as filed. A dash means the figure was not present on the return — not that it was zero.

Other returns filed

• 2023 · 990-T

  Revenue

  — not reported

  Expenses

  — not reported

  Assets (EOY)

  — not reported

• 2022 · 990-T

  Revenue

  — not reported

  Expenses

  — not reported

  Assets (EOY)

  — not reported

• 2021 · 990

  Revenue

  $5,457,678

  Expenses

  $6,759,977

  Assets (EOY)

  $931,015

• 2020 · 990

  Revenue

  $5,504,252

  Expenses

  $5,521,642

  Assets (EOY)

  $909,214

• 2019 · 990

  Revenue

  $5,289,061

  Expenses

  $5,168,390

  Assets (EOY)

  $931,167

• 2018 · 990

  Revenue

  $4,158,429

  Expenses

  $4,044,421

  Assets (EOY)

  $691,169

• 2017 · 990

  Revenue

  $2,616,405

  Expenses

  $2,629,032

  Assets (EOY)

  $428,284

• 2016 · 990

  Revenue

  $2,540,856

  Expenses

  $2,528,958

  Assets (EOY)

  $157,091

• 2015 · 990

  Revenue

  $2,854,685

  Expenses

  $2,850,153

  Assets (EOY)

  $230,345

• 2014 · 990

  Revenue

  $2,585,270

  Expenses

  $2,565,175

  Assets (EOY)

  $430,335

Nonprofiteer parses Forms 990, 990-EZ and 990-PF, in a window of recent tax years. These returns are recorded from the IRS e-file index, so their figures were extracted by that index rather than read from the return here — treat them as a different source from the filings above, not as more of the same record. A dash means the index carries no figure; Form 990-T listings carry none at all. Showing the 10 most recent; the API carries the rest.

Grants made

No itemized grants to organizations. Schedule I is filed only by organizations that granted more than $5,000 to a recipient, so most filers have none.

Grants received

• CARNEGIE MELLON UNIVERSITY

  $506,446

  2024 · EDUCATION/RESEARCH

• CARNEGIE MELLON UNIVERSITY

  $450,943

  2022 · EDUCATION/RESEARCH SUBCONTRACTS

• CARNEGIE MELLON UNIVERSITY

  $316,640

  2023 · EDUCATION/RESEARCH

• SCRIPPS RESEARCH INSTITUTE

  $165,644

  2022 · GRANTS FOR SCIENTIFIC RESEARCH

• RANCHO SANTA FE FOUNDATION

  $100,000

  2022 · HEALTH

• THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND

  $42,676

  2024 · SUBCONTRACT GRANT AWARD

• THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND

  $42,419

  2024 · SUBCONTRACT GRANT AWARD

• THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND

  $41,325

  2024 · SUBCONTRACT GRANT AWARD

• MEDICAL RESEARCH CHARITIES INC

  $41,071

  2022 · TO ASSIST IN THE ORGANIZATION'S EXEMPT PURPOSES.

• THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND

  $36,053

  2024 · SUBCONTRACT GRANT AWARD

The 10 largest by cash amount. The API serves every itemized grant.

Related organizations

From Schedule R Part II, where a filer lists the tax-exempt organizations it is related to by control. It does not record shared board members or money.

Other IRS files