- Revenue 2024
- $31,755,677
- Expenses 2024
- $36,999,068
Program services were 91.3% of total expenses calculated — Part IX's program-services column over total expenses, both as filed.
As filed
- Subsection
- 03
- NTEE code
- H83
- Classification
- 2000
- Street
- 34 WASHINGTON ST STE 230
These codes are the IRS's own and are shown exactly as filed. What each one means is in the Business Master File documentation (opens in a new tab).
Mission and programs · 2024
Mission
TO FUND RESEARCH WITH THE HIGHEST PROBABILITY OF PREVENTING, SLOWING OR REVERSING ALZHEIMER'S DISEASE. ALL OVERHEAD EXPENSES ARE PAID BY THE BOARD OF DIRECTORS, TRUSTEES AND CORE GROUP OF SELECT DONORS, ALLOWING 100% OF GENERAL DONATIONS TO FUND OUR RESEARCH PROGRAMS.
Activities or mission (Part I)
TO FUND RESEARCH WITH THE HIGHEST PROBABILITY OF PREVENTING, SLOWING OR REVERSING ALZHEIMER'S DISEASE.
-
IN 2024, CURE ALZHEIMER'S FUND SUPPORTED 120 RESEARCH PROJECTS AT 66 LEADING RESEARCH INSTITUTIONS, FOR RESEARCH OUTPUT OF $30 MILLION. MANY PROJECTS PURSUED A DEEPER UNDERSTANDING OF THE MECHANISMS OF ACTION OF THE GENES AND VARIANTS WITH THE BIGGEST IMPACT ON RISK AND TIMING OF ALZHEIMER'S DISEASE. OTHER PROJECTS PURSUED NOVEL THEORIES AND TOOLS TO ASSESS POTENTIAL AVENUES FOR PREVENTION AND TREATMENT, IN PARTICULAR REGARDING THE ROLE OF NEUROINFLAMMATION, THE GUT MICROBIOME, AND THE IMMUNE SYSTEM IN HEALTHY BRAIN FUNCTION. ADDITIONAL EXPENSES INCLUDE HUSBANDRY OF TRANSGENIC ANIMAL MODELS BY A CONTRACT RESEARCH ORGANIZATION; THE DIRECT SUPPORT OF FACILITATING GRANTS AND THE AWARD PROCESS; AND COSTS ASSOCIATED WITH ASSESSING RESEARCH PROPOSALS AND DETERMINING FUNDING PRIORITIES.
Expenses $30,000,392 · Grants $28,828,950
-
CREATING AWARENESS TOOK THE FORM OF MAILINGS, OUTREACH, WEBINARS, AND SUPPORT OF THIRD PARTY EVENTS DESIGNED TO RAISE AWARENESS ABOUT THE NEED OF MORE RESEARCH INTO THE ORIGINS AND PROGRESSION OF ALZHEIMER'S DISEASE.
Expenses $3,783,862
As filed on the 2024 return.
Officers and directors · 2024
As listed in Part VII of the 2024 return, in the order the filer printed them. Each return names its own; this is not a roster the organization keeps with us.
-
Margaret E SmithMARGARET E SMITH
CEO
- Total calculated
- $455,433
- From this org
- $426,320
- From related orgs
- $0
- Other
- $29,113
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $407,378
- Bonus
- $18,942
- Other
- $0
- Deferred
- $10,350
- Nontaxable benefits
- $18,763
- Filer's total
- $455,433
-
Henry McCanceHENRY MCCANCE
CHAIR
- Total calculated
- $0
- Hours/week
- 5
-
Phyllis RappaportPHYLLIS RAPPAPORT
TREASURER
- Total calculated
- $0
- Hours/week
- 5
-
Timothy ArmourTIMOTHY ARMOUR
DIRECTOR
- Total calculated
- $0
- Hours/week
- 3
-
Richard BirnbaumRICHARD BIRNBAUM
DIRECTOR
- Total calculated
- $0
- Hours/week
- 4
-
Mark FaggianoMARK FAGGIANO
DIRECTOR (FROM 10/24)
- Total calculated
- $0
- Hours/week
- 3
-
Mary Greenhill CaglieroMARY GREENHILL CAGLIERO
DIRECTOR (FROM 10/24)
- Total calculated
- $0
- Hours/week
- 3
-
Robert GreenhillROBERT GREENHILL
DIRECTOR (TO 10/24)
- Total calculated
- $0
- Hours/week
- 3
-
Kumar MahadevaKUMAR MAHADEVA
DIRECTOR (FROM 12/24)
- Total calculated
- $0
- Hours/week
- 3
-
Jacqueline MorbyJACQUELINE MORBY
DIRECTOR
- Total calculated
- $0
- Hours/week
- 4
-
Josephine AntonellisJOSEPHINE ANTONELLIS
CFO
- Total calculated
- $207,441
- From this org
- $200,226
- From related orgs
- $0
- Other
- $7,215
- Hours/week
- 30
Schedule J breakdown matched by us
- Base
- $190,226
- Bonus
- $10,000
- Other
- $0
- Deferred
- $6,014
- Nontaxable benefits
- $1,201
- Filer's total
- $207,441
-
Laurel LyleLAUREL LYLE
SECRETARY & VP BOARD RELATIONS & DEV OPS
- Total calculated
- $125,326
- From this org
- $121,094
- From related orgs
- $0
- Other
- $4,232
- Hours/week
- 30
-
Katharine HermanKATHARINE HERMAN
EVP DEVELOPMENT
- Total calculated
- $448,817
- From this org
- $418,581
- From related orgs
- $0
- Other
- $30,236
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $342,381
- Bonus
- $76,200
- Other
- $0
- Deferred
- $10,350
- Nontaxable benefits
- $19,886
- Filer's total
- $448,817
-
Julie HarrisJULIE HARRIS
EVP RESEARCH MGMT (TO 12/24)
- Total calculated
- $306,210
- From this org
- $296,359
- From related orgs
- $0
- Other
- $9,851
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $276,634
- Bonus
- $19,725
- Other
- $0
- Deferred
- $8,891
- Nontaxable benefits
- $960
- Filer's total
- $306,210
-
Barbara ChambersBARBARA CHAMBERS
EVP MARKETING & COMM.
- Total calculated
- $290,642
- From this org
- $267,548
- From related orgs
- $0
- Other
- $23,094
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $246,348
- Bonus
- $21,200
- Other
- $0
- Deferred
- $8,403
- Nontaxable benefits
- $14,691
- Filer's total
- $290,642
-
Lisa RandLISA RAND
VP MARKETING & COMM.
- Total calculated
- $217,835
- From this org
- $199,320
- From related orgs
- $0
- Other
- $18,515
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $194,120
- Bonus
- $5,200
- Other
- $0
- Deferred
- $6,268
- Nontaxable benefits
- $12,247
- Filer's total
- $217,835
-
Daniel HarperDANIEL HARPER
VP DEVELOPMENT
- Total calculated
- $208,193
- From this org
- $195,493
- From related orgs
- $0
- Other
- $12,700
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $189,293
- Bonus
- $6,200
- Other
- $0
- Deferred
- $5,959
- Nontaxable benefits
- $6,741
- Filer's total
- $208,193
-
John SlatteryJOHN SLATTERY
SVP, PHILANTHROPIC PARTNERSHIPS
- Total calculated
- $205,775
- From this org
- $198,792
- From related orgs
- $0
- Other
- $6,983
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $189,592
- Bonus
- $9,200
- Other
- $0
- Deferred
- $6,054
- Nontaxable benefits
- $929
- Filer's total
- $205,775
-
Mahua DasguptaMAHUA DASGUPTA
SR. PHILANTROPIC ADVISOR
- Total calculated
- $203,654
- From this org
- $178,255
- From related orgs
- $0
- Other
- $25,399
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $172,055
- Bonus
- $6,200
- Other
- $0
- Deferred
- $5,690
- Nontaxable benefits
- $19,709
- Filer's total
- $203,654
-
Thidaphorn SengsavanhTHIDAPHORN SENGSAVANH
DIRECTOR OF DEVELOPMENT OPS
- Total calculated
- $178,296
- From this org
- $154,055
- From related orgs
- $0
- Other
- $24,241
- Hours/week
- 40
Schedule J breakdown matched by us
- Base
- $146,855
- Bonus
- $7,200
- Other
- $0
- Deferred
- $4,883
- Nontaxable benefits
- $19,358
- Filer's total
- $178,296
Compensation is as filed in Part VII: reportable pay from this organization and from related organizations, other compensation, and hours per week. The total, marked calculated, is our sum of the three dollar columns, with a blank column counted as $0; the form itself has no total. On a Form 990-EZ the columns are Part IV's instead, and on a Form 990-PF Part VIII's — compensation, contributions to benefit plans, and expense account — and the total sums those. A Schedule J breakdown is as filed: base pay, bonus, other, deferred compensation and nontaxable benefits from this organization, with any from related organizations beside each, and the filer's own total. It is shown with the Part VII listing of the same name on the same return. The form gives no key between the two, so that pairing is ours, and is marked matched by us. Earlier years are each on their own filing page.
Filings
-
2024
- Revenue
- $31,755,677
- Expenses
- $36,999,068
- Contributions
- $30,788,755
- Grants paid
- $28,828,950
-
2023
- Revenue
- $37,725,207
- Expenses
- $34,633,548
- Contributions
- $36,697,205
- Grants paid
- $26,431,117
-
2022
- Revenue
- $40,708,245
- Expenses
- $30,613,014
- Contributions
- $32,354,655
- Grants paid
- $23,431,727
The four totals the IRS asks for on Part I of the Form 990, as filed. A dash means the figure was not present on the return — not that it was zero.
Other returns filed
-
2021 · 990
- Revenue
- $26,572,727
- Expenses
- $23,165,275
- Assets (EOY)
- $23,967,152
-
2020 · 990
- Revenue
- $22,899,223
- Expenses
- $21,006,379
- Assets (EOY)
- $16,427,042
-
2019 · 990
- Revenue
- $30,582,733
- Expenses
- $24,308,027
- Assets (EOY)
- $13,454,870
-
2018 · 990
- Revenue
- $19,893,795
- Expenses
- $23,629,311
- Assets (EOY)
- $7,580,826
-
2017 · 990
- Revenue
- $17,498,111
- Expenses
- $18,999,554
- Assets (EOY)
- $10,939,018
-
2017 · 990
- Revenue
- $17,498,111
- Expenses
- $18,999,554
- Assets (EOY)
- $10,939,018
-
2016 · 990
- Revenue
- $16,157,156
- Expenses
- $16,515,434
- Assets (EOY)
- $12,463,210
-
2015 · 990
- Revenue
- $11,247,926
- Expenses
- $13,040,698
- Assets (EOY)
- $12,424,725
-
2014 · 990
- Revenue
- $12,652,179
- Expenses
- $7,290,816
- Assets (EOY)
- $14,274,392
-
2013 · 990
- Revenue
- $6,382,414
- Expenses
- $6,389,034
- Assets (EOY)
- $8,947,500
Nonprofiteer parses Forms 990, 990-EZ and 990-PF, in a window of recent tax years. These returns are recorded from the IRS e-file index, so their figures were extracted by that index rather than read from the return here — treat them as a different source from the filings above, not as more of the same record. A dash means the index carries no figure; Form 990-T listings carry none at all. Showing the 10 most recent; the API carries the rest.
Grants made
-
MASSACHUSETTS GENERAL HOSPITAL
$1,955,000
2022 THECUREALZALZHEIMERS GENOME PROJECT
-
MASSACHUSETTS GENERAL HOSPITAL
$1,955,000
2023 THE CUREALZ ALZHEIMER'S GENOME PROJECT
-
MASSACHUSETTS GENERAL HOSPITAL
$1,955,000
2024 THE CUREALZ ALZHEIMER'S GENOME PROJECT
-
$575,000
2024 APOE: APOE4 ACCELERATES CD8 EXHAUSTION VIA GLUCOCORTICOID SIGNALING IN ALZHEIMER'S FEMALE CARRIERS
-
$431,250
2023 A NEW MODEL OF MICROGLIA GENETIC PERTURBATION IN VIVO TO SCREEN ALL RISK FACTORS ASSOCIATED WITH ALZHEIMER'S DISEASE
-
2024 SEX-BIASED TLR7 SIGNALING IN DEMYELINATION AND ITS INHIBITION BY SMALL MOLECULES
-
$345,000
2022 APOE CONSORTIUM: ROLE OF APOE ISOFORMS IN IMMUNE RESPONSES IN A MODEL OF TAUOPATHY
-
$345,000
2022 BEE: CROSSTALK OF CNS BARRIERS AND CLEARANCE ROUTES IN HOMEOSTASIS AND ALZHEIMERS DISEASE
-
MASSACHUSETTS GENERAL HOSPITAL
$345,000
2023 NEUROPROTECTIVE EFFECTS OF THE EXERCISE HORMONE IRISIN IN ALZHEIMER'S DISEASE
-
$345,000
2023 MBC: INTERACTION OF THE MICROBIOME WITH ASTROCYTES AND AMYLOID PATHOLOGY
The 10 largest by cash amount. The API serves every itemized grant.
Grants received
-
FIDELITY INVESTMENTS CHARITABLE GIFT FUND
$2,857,239
2024 For grant recipient's exempt purposes
-
FIDELITY INVESTMENTS CHARITABLE GIFT FUND
$2,021,013
2023 For grant recipient's exempt purposes
-
$1,964,671
2023 UNRESTRICTED
-
FIDELITY INVESTMENTS CHARITABLE GIFT FUND
$1,324,253
2022 For grant recipient's exempt purposes
-
DONOR ADVISED CHARITABLE GIVING
$1,007,106
2024 HEALTH
-
DONOR ADVISED CHARITABLE GIVING
$960,967
2023 HEALTH
-
DONOR ADVISED CHARITABLE GIVING
$611,701
2022 HEALTH
-
UNIVERSITY OF NOTRE DAME DU LAC
$500,000
2022 See Part IV
-
$500,000
2024 PROVIDE GENERAL OPERATING SUPPORT
-
$474,965
2024 UNRESTRICTED
The 10 largest by cash amount. The API serves every itemized grant.
Other IRS files
Auto-Revocation List
Not listed. The IRS publishes this list for organizations whose exemption was automatically revoked for failing to file for three consecutive years.
Publication 78
Listed as of 13 October 2026, under deductibility PC.
These are two separate IRS files on two separate schedules, shown as published and not reconciled with each other. Neither is a statement about whether a contribution is deductible today: 19,245 organizations appear in Publication 78 while the IRS's own revocation file lists them as currently revoked, more than half of those revoked before 2019. Absence from Publication 78 is evidence of nothing, and presence is not evidence either. Verify current status with the IRS before relying on it.
What this page reflects
The registration facts above come from the IRS Business Master File published 13 October 2026 and read 29 October 2026, for every organization at once. Returns through tax year 2024, the newest we have parsed for this organization.