Form 990 for tax year 2024

Totals

Total revenue

$12,475,933

Total expenses

$17,043,595

Contributions and grants received

$12,339,343

Grants paid

$3,014,488

Program service revenue

$0

Investment income

$136,590

Other revenue

$0

Total assets, end of year

$2,040,922

Total liabilities, end of year

$1,719,346

Net assets or fund balances, end of year

$321,576

Program services expenses (Part IX)

$16,124,944

Management and general expenses

$918,651

Fundraising expenses

$0

Program service expenses (Part III)

$16,124,944

Program services were 94.6% of total expenses calculated — Part IX's program-services column over total expenses, both as filed.

Line items

Every line the filer filed in Parts VIII, IX and X, as filed and in filed order. Blank columns are left out, and the lines are not forced to add up to the totals above.

Mission and programs · 2024

• AD Workbench - a free, secure, cloud-based data sharing and analytics environment - is the interoperability layer of the AD Data Initiative technical suite and its flagship product offering. AD Workbench empowers researchers around the world to share, access, and analyze data across platforms. It provides data hosting, offers collaborative workspaces, and supports federated and distributed data sharing via FDSA.There are currently 8,400+ registered AD Workbench users from across 120 countries with access to over 800K participant records. Through AD Workbench, researchers and institutions can accelerate progress towards new and better treatments and diagnostic tools for Alzheimer's disease and related dementias.

  Expenses $5,168,435

• Global Research Platforms - GRIP is a secure, cloud-based, and open-access platform designed to help researchers integrate, analyze, and share complex biomedical data with ease. It is a multi-site, multi-modal collaboration platform with co-developed, modular tools, workflows, and workspaces that enable secure data sharing, analysis, and collaboration.

  Expenses $5,091,974 · Grants $50,000

• The AD Data Initiative product suite consists of data sharing and analytic products along with enabling technical resources to empower researchers around the world to share, access and analyze data across multiple platforms. AD Workbench is the interoperability layer of the AD Data Initiative technical suite and its flagship product offering. There are currently more than 120 datasets accessible via AD Workbench - including clinical tabular data, imaging, omics and biosamples. The AD Data Initiative works closely with data contributors and data platform partners to ensure interoperability with AD data-sharing platforms and data accessibility across the global Alzheimer's data ecosystem.

  Expenses $2,932,616 · Grants $2,414,488

• Core to the AD Data Initiative's mission is the belief that data sharing and global collaboration will accelerate progress, seed innovation and lead to breakthroughs faster. AD Data Initiative is advancing a scientific strategy and investing in strategic initiatives to foster global collaboration, empower researchers and advance scientific discovery. These initiatives include: the William H. Gates Sr. Fellowship Program, Global Data Challenges, Scientific Driver Projects and Global Research Collaborations and Consortia. This scientific strategy and the AD Data Initiative's programmatic efforts are guided by an evolving list of priority research questions that have been shaped by insights from Advisory Board members, input from the AD research community and engagement with thought leaders in Alzheimer's and related dementias research.

  Expenses $2,270,057 · Grants $550,000

• The AD Data Initiative amplifies its mission through communications and engagement: website, social media, conferences and events, partnership campaigns/communications and special projects. These efforts expand access to important datasets, broaden the use of data platforms and tools, and foster global collaboration to accelerate discovery.

  Expenses $661,862

As filed on the 2024 return. The filer continues this part on Schedule O, which is not shown here.

Listed in Part VII

Compensation is as filed in Part VII: reportable pay from this organization and from related organizations, other compensation, and hours per week. The total, marked calculated, is our sum of the three dollar columns, with a blank column counted as $0; the form itself has no total. On a Form 990-EZ the columns are Part IV's instead, and on a Form 990-PF Part VIII's — compensation, contributions to benefit plans, and expense account — and the total sums those.

Grants on this return

• Davos Alzheimer's Collaborative (DAC)

  $225,000

  Connecting with and supporting the sharing of data from multiple sites in low-middle income countries to more accurately represent the global population

• Georgia State University Research Foundation (GSU)

  $200,000

  Understanding the specific and unique challenges that investigators in other countries face when trying to make their data shareable with the larger community of researchers

• Sage Bionetworks

  $195,000

  Data platform interoperability

• Answer ALS

  $150,000

  Data platform interoperability

• American Heart Association (AHA)

  $125,289

  Data platform interoperability

• Alleo Labs Corporation

  $50,000

  Gates Sr. AD Fellowship recipient award

• State of Maryland University of Maryland Baltimore

  $50,000

  Gates Sr. AD Fellowship recipient award

• University of California San Francisco (UCSF)

  $50,000

  Project start for GRIP Vision-Language Machine Learning (ML) Models for Brain Image Analysis

• Washington University in St Louis

  $50,000

  Gates Sr. AD Fellowship recipient award

Related organizations on this return

Schedule R Part II: tax-exempt organizations related to the filer by control. It does not record shared board members or money.

• BREAKTHROUGH ENERGY CATALYST FOUNDATION

  501(c)(3) · SCIENTIFIC · DE · controlled entity

  Directly controlled by NA

• BREAKTHROUGH ENERGY ACTION INC

  501(c)(4) · ADVOCACY · DE · controlled entity

  Directly controlled by NA

• BREAKTHROUGH ENERGY FOUNDATION

  501(c)(3) · SCIENTIFIC · DE · controlled entity

  Directly controlled by NA

Taxable family on this return

Schedule R Parts I, III and IV, as filed. These record ownership and control, not shared board members or money moved.

Provenance

Return type

form_990

Tax year

2024

Filed

13 November 2025

IRS schema version

2024v5.1

Source object

202543179349302149

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