INSTITUTE FOR SYSTEMS BIOLOGY

As filed

Subsection

03

NTEE code

U500

Classification

8000

Street

401 TERRY AVE N

These codes are the IRS's own and are shown exactly as filed. What each one means is in the Business Master File documentation (opens in a new tab).

Mission and programs · 2024

• SEE SCHEDULE OAT PROVIDENCE, WE USE OUR VOICE TO ADVOCATE FOR VULNERABLE POPULATIONS AND NEEDED REFORMS IN HEALTH CARE. WE ARE ALSO PURSUING INNOVATIVE WAYS TO TRANSFORM HEALTH CARE BY KEEPING PEOPLE HEALTHY, AND MAKING OUR SERVICES MORE CONVENIENT, ACCESSIBLE AND AFFORDABLE FOR ALL. IN AN INCREASINGLY UNCERTAIN WORLD, WE ARE COMMITTED TO HIGH-QUALITY, COMPASSIONATE HEALTH CARE FOR EVERYONE - REGARDLESS OF COVERAGE OR ABILITY TO PAY. WE HELP PEOPLE AND COMMUNITIES BENEFIT FROM THE BEST HEALTH CARE MODEL FOR THE FUTURE - TODAY.TOGETHER, OUR 125,000 CAREGIVERS (ALL EMPLOYEES) SERVE IN 51 HOSPITALS, 1,014 CLINICS AND A COMPREHENSIVE RANGE OF HEALTH AND SOCIAL SERVICES ACROSS ALASKA, CALIFORNIA, MONTANA, NEW MEXICO, OREGON, TEXAS AND WASHINGTON. THE PROVIDENCE AFFILIATE FAMILY INCLUDES:-PROVIDENCE ACROSS FIVE WESTERN STATES-COVENANT HEALTH IN WEST TEXAS AND NEW MEXICO-FACEY MEDICAL GROUP IN LOS ANGELES, CA-KADLEC IN SOUTHEAST WASHINGTON-PACIFIC MEDICAL CENTERS IN SEATTLE, WA-SWEDISH HEALTH SERVICES IN SEATTLE, WAIN 2024, PROVIDENCE MINISTRIES AND AFFILIATES PROVIDED $1.9 BILLION IN COMMUNITY BENEFIT PROGRAMS. THIS INCLUDES FREE AND DISCOUNTED CARE, UNCOMPENSATED AND SUBSIDIZED CARE, AND OTHER COMMUNITY HEALTH ACTIVITIES.ONE OF THESE VITAL PROGRAMS, MEDICAID, IS A LIFELINE FOR MILLIONS OF INDIVIDUALS, INCLUDING SENIORS, CHILDREN, PREGNANT PATIENTS, THOSE WITH DISABILITIES AND VETERANS. WE ARE GRATEFUL TO EVERYONE IN OUR COMMUNITIES WHO HAS JOINED US IN ADVOCATING FOR CONTINUED FUNDING AND EXPANSION OF THIS PROGRAM. TOGETHER, WE ARE HELPING TO ENSURE MORE PEOPLE HAVE ACCESS TO NEEDED CARE.FOR MORE INFORMATION GO TO: HTTPS://WWW.PROVIDENCE.ORG/ABOUT/ANNUAL-REPORTTHROUGH OUR COMMUNITY BENEFIT PROGRAMS, WE FOCUS ON MEETING THE DIVERSE NEEDS OF THE PEOPLE WE SERVE BY WORKING TO ENSURE BASIC HEALTH NEEDS ARE MET, REMOVING BARRIERS TO CARE, BUILDING COMMUNITY RESILIENCE AND INNOVATING FOR THE FUTURE. PROVIDENCE CONTINUES TO WORK TOWARDS CARBON NEGATIVE AND IN 2024 DECREASED EMISSIONS BY 19 PERCENT COMPARED TO OUR 2019 BASELINE. OUR EFFORTS EARNED US A SYSTEM RECORD 55 ENVIRONMENTAL EXCELLENCE AWARDS FROM PRACTICE GREENHEALTH AND MADE US THE FIRST LARGE SYSTEM TO RECEIVE THE JOINT COMMISSION'S SUSTAINABLE HEALTHCARE CERTIFICATION IN 2024 FOR EACH OF OUR HOSPITALS.PROGRAM SERVICE ACCOMPLISHMENTSBIOMOLECULAR RESEARCH: IN 2024, ISB RESEARCHERS PUBLISHED 131 ACADEMIC RESEARCH PAPERS IN A RANGE OF HIGH-PROFILE JOURNALS. TOPICS COVERED INCLUDED COVID-19, GENOMICS, MICROFLUIDICS, PROTEOMICS, HIGH-THROUGHPUT COMPUTATION, MULTISCALE MODELING, SYSTEMS BIOLOGY APPLICATIONS, BIOINFORMATICS, GLOBAL HEALTH, AND CANCERS.ISB EDUCATION & OUTREACHISB EDUCATION'S PROGRAM ACTIVITIES REPORTED FOR THE 2024/25 SCHOOL YEAR ARE LISTED BELOW IN FIVE CATEGORIES.OUR VISION IS THAT STUDENTS GRADUATE READY TO LEARN, THRIVE, WORK AND ENGAGE IN A STEM-RICH SOCIETY. WE WANT EVERY STUDENT TO HAVE AN OPPORTUNITY TO DO REAL SCIENCE WE BRING CURRENT SCIENCE AND AUTHENTIC PRACTICES TO SCHOOLS.1- COMBINED ACTIVITIES ACROSS TWO ISB EDUCATION GROUPSPARTNERS AND FUNDERS:-12 MONTHLY IMPACT STORIES WERE WRITTEN BY THE ISB EDUCATION TEAM TO COMMUNICATE REGULARLY WITH PARTNERS AND FUNDERS. HTTPS://ISBSCIENCE.ORG/NEWS/EDUCATION/2024-25-SCHOOL-YEAR-ISB-EDUCATION-HIGHLIGHTS/-10 PARTNERSHIPS CONTINUES, WITH REGIONAL SCHOOL DISTRICTS AND OTHER NON-PROFIT ORGANIZATIONS-7 PRESENTATIONS WERE GIVEN AT EVENTS FOR REGIONAL, STATE, AND NATIONAL AUDIENCES.SCHOOL SYSTEMS: "CLIMETIME" HTTPS://WWW.CLIMETIME.ORG/CBO-GRANTEES/ISB/-4 WORKSHOP SERIES WERE PROVIDED FOR ELEMENTARY AND SECONDARY SCIENCE TEACHERS.-93 EDUCATORS, ACROSS THE RANGE OF GRADES: ELEMENTARYMIDDLE-AND HIGH SCHOOL.-35 SCHOOL DISTRICTS HAD EDUCATORS PARTICIPATING IN THE EVENTS.-8 EDUCATIONAL SERVICE DISTRICT REGIONS ACROSS WA STATE HAD EDUCATORS PARTICIPATING IN THE EVENTS.STEM PROFESSIONALS:-50+ STEM PROFESSIONALS CONTRIBUTED TO THE ABOVE EDUCATION ACTIVITIES, TO SUPPORT LEARNING EXPERIENCES FOR STUDENTS, TEACHERS, AND PRINCIPALS.2- BALIGA LAB'S SYSTEMS EDUCATION EXPERIENCES K-12 STUDENT-TEACHER-SCIENTIST PARTNERSHIPS HTTPS://SEE.ISBSCIENCE.ORG/STUDENTS:-181 TOTAL: HIGH SCHOOL STUDENTS-SYSTEMS THINKERS IN STEM AMBASSADORS-RESEARCH INTERNS-WANIC COURSE-"ENVIRONMENTAL IN THE OUTDOORS RESEARCH EXPERIENCE" (ESORE)-LEADERSHIP, EMPOWERMENT, AND DEVELOPMENT IN STEMAMERICORPS MEMBERS:-2 AMERICORPS MEMBERS LEADING "SUPPORT SYSTEM FOR ISB'S INTERNS AND "WRAP AROUND STUDENT SUPPORT"TO ADDRESS ONGOING STUDENT NEEDS.TEACHERS:-3 TEACHER INTERNS-2 STAR FELLOWSSEE-RESOURCES FOR CLASSROOMS:-4 TEACHERS IN 4 DIFFERENT SCHOOLS IMPLEMENTING "SYSTEMS MEDICINE"(NEW CTE COURSE COMPRISED OF 4 DRAFT CURRICULUM MODULES)-3 ADDITIONAL CURRICULUM MODULES IN DEVELOPMENT, "CARBON'S FATE", "MICROPLASTICS", "RULES OF LIFE" WHICH HAS THREE SUB-SECTIONS.3- LOGAN CENTER FOR EDUCATION K-12 SCHOOL DISTRICT PARTNERSHIPS + STATE LEADERS PARTNERSHIP HTTPS:/LOGANCENTER.ISBSCIENCE.ORG/WHOLE SCHOOL SYSTEMS: WE CONTINUED PARTNERSHIPS SCHOOL DISTRICTS ACROSS THE PUGET SOUND REGION ON THEIR K-12 SCIENCE/STEM PROGRAMS.-24 HIGH SCHOOL SCIENCE TEACHERS (ALL OF THEM) WERE SUPPORTED IN YEAR 2 OF A 5-YEAR PARTNERSHIP WITH CENTRAL KITSAP SCHOOL DISTRICT.-12 SCHOOL AND DISTRICT-LEVEL ADMINISTRATORS FROM 5 SCHOOL DISTRICTS PARTICIPATED IN A 6 PART COURSE "PRINCIPLES OF SCIENCE FOR PRINCIPALS."-5 DISTRICT LEADERS PARTICIPATED IN THE "SECONDARY STEM PROJECT" MONTHLY LEADERSHIP TEAM PLANNING SESSIONS.DISTRICT SCIENCE LEADERS:-9 REGIONAL DIRECTORS: AS CO-DIRECTOR OF WASHINGTON STATE LASER, WE PROVIDED MONTHLY PROFESSIONAL GROWTH SESSIONS FOR SCIENCE LEADERS, COVERING ALL WA SCHOOL DISTRICTS.-22 SCHOOL DISTRICT SCIENCE/STEM LEADERS: AS DIRECTOR OF PUGET SOUND LASER ALLIANCE, 1 OF THE 9 REGIONS, WE PROVIDED MONTHLY PROFESSIONAL GROWTH SESSIONS FOR SCIENCE LEADERS OF THIS COLLABORATIVE ACROSS KING AND PIERCE COUNTIES; 22 OF 36 DISTRICTS PARTICIPATED.4- POST-SECONDARY SCIENCE EDUCATIONCOMMUNITY COLLEGES: "NEXT-GEN BIOLOGY LEARNING NETWORK"-35 COMMUNITY AND TECHNICAL COLLEGES AND NEXT-GEN BIOLOGISTS FROM NON-DEGREE GRANTING RESEARCH INSTITUTES IN WASHINGTON PARTICIPATED IN YEAR 3 OF 5 OF A NATIONAL SCIENCE FOUNDATION GRANT - RESEARCH COORDINATION NETWORK (RCN): 2020/21 INCUBATOR TO BUILD READINESS AND CAPACITY. 2021-2026 NETWORK TO BUILD A BENEFICIAL BRIDGE, WITH 2-WAY LEARNING FOR ISB SCIENTISTS, OTHER NEXT-GEN BIOLOGISTS AND THE CC FACULTY AND STUDENTS.UNDERGRADUATE STUDENTS: "ISB RESEARCH INTERNS"-11 RESEARCH INTERNS ACROSS 75% OF ISB RESEARCH LABS. FUNDED BY AN NSF RESEARCH EXPERIENCES FOR UNDERGRADUATES GRANT YEAR 3, AND OTHER FUNDING SOURCES OBTAINED FOR SOME STUDENTS. 10 MENTORS TRAINED ON HOW TO GUIDE STUDENTS WITH EFFECTIVE FEEDBACK.5- COMMUNITY OUTREACHHIGH SCHOOL GROUPS: "ISB TOUR / CAREER PATHWAYS EXPERIENCE"-3 TOUR GROUPS CAME TO ISB IN-PERSON FOR A LEARNING EXPERIENCEISB ALSO HELD VARIOUS SYMPOSIA, SEMINARS, AND WORKSHOPS TO DISSEMINATE BASIC KNOWLEDGE ABOUT SYSTEMS BIOLOGY AND CREATE DIALOG ABOUT LEADING-EDGE TOPICS.

  Expenses $33,822,669 · Revenue $822,273

As filed on the 2024 return. The filer continues this part on Schedule O, which is not shown here.

Officers and directors · 2024

As listed in Part VII of the 2024 return, in the order the filer printed them. Each return names its own; this is not a roster the organization keeps with us.

The first 25 listed. Compensation is as filed in Part VII: reportable pay from this organization and from related organizations, other compensation, and hours per week. The total, marked calculated, is our sum of the three dollar columns, with a blank column counted as $0; the form itself has no total. On a Form 990-EZ the columns are Part IV's instead, and on a Form 990-PF Part VIII's — compensation, contributions to benefit plans, and expense account — and the total sums those. A Schedule J breakdown is as filed: base pay, bonus, other, deferred compensation and nontaxable benefits from this organization, with any from related organizations beside each, and the filer's own total. It is shown with the Part VII listing of the same name on the same return. The form gives no key between the two, so that pairing is ours, and is marked matched by us. Earlier years are each on their own filing page.

Filings

• 2024

  Revenue

  $42,255,091

  Expenses

  $47,550,054

  Contributions

  $37,859,571

  Grants paid

  $0

• 2023

  Revenue

  $43,611,326

  Expenses

  $46,752,331

  Contributions

  $40,929,618

  Grants paid

  $0

• 2022

  Revenue

  $37,072,888

  Expenses

  $41,968,785

  Contributions

  $34,972,830

  Grants paid

  $0

The four totals the IRS asks for on Part I of the Form 990, as filed. A dash means the figure was not present on the return — not that it was zero.

Other returns filed

• 2024 · 990-T

  Revenue

  — not reported

  Expenses

  — not reported

  Assets (EOY)

  — not reported

• 2023 · 990-T

  Revenue

  — not reported

  Expenses

  — not reported

  Assets (EOY)

  — not reported

• 2022 · 990-T

  Revenue

  — not reported

  Expenses

  — not reported

  Assets (EOY)

  — not reported

• 2021 · 990

  Revenue

  $43,313,392

  Expenses

  $38,933,529

  Assets (EOY)

  $81,550,518

• 2021 · 990-T

  Revenue

  — not reported

  Expenses

  — not reported

  Assets (EOY)

  — not reported

• 2020 · 990

  Revenue

  $39,847,320

  Expenses

  $40,513,307

  Assets (EOY)

  $80,193,323

• 2020 · 990-T

  Revenue

  — not reported

  Expenses

  — not reported

  Assets (EOY)

  — not reported

• 2019 · 990

  Revenue

  $36,230,866

  Expenses

  $41,016,030

  Assets (EOY)

  $73,280,105

• 2018 · 990

  Revenue

  $31,249,334

  Expenses

  $33,125,028

  Assets (EOY)

  $74,178,732

• 2018 · 990

  Revenue

  $31,249,334

  Expenses

  $33,125,028

  Assets (EOY)

  $74,178,732

Nonprofiteer parses Forms 990, 990-EZ and 990-PF, in a window of recent tax years. These returns are recorded from the IRS e-file index, so their figures were extracted by that index rather than read from the return here — treat them as a different source from the filings above, not as more of the same record. A dash means the index carries no figure; Form 990-T listings carry none at all. Showing the 10 most recent; the API carries the rest.

Grants made

No itemized grants to organizations. Schedule I is filed only by organizations that granted more than $5,000 to a recipient, so most filers have none.

Grants received

• MAYO CLINIC GROUP RETURN

  $1,007,351

  2022 · SUPPORT CHARITABLE PURPOSE

• PROVIDENCE HEALTH & SERVICES WASHINGTON

  $741,940

  2022 · OPERATIONAL SUPPORT

• PARKER INSTITUTE FOR CANCER IMMUNOTHERAPY

  $547,924

  2022 · SUPPORT RESEARCH IN FIELD OF CANCER IMMUNOTHERAPY

• MAYO CLINIC GROUP RETURN

  $445,307

  2023 · SUPPORT RESEARCH PROGRAM

• EVERY CURE INC

  $391,997

  2025 · CURATE, EVALUATE AND INTEGRATE LARGE BIOMEDICAL DATASETS

• SAGE BIONETWORKS

  $379,595

  2023 · CRI Immune Atlas4: Platform for immune-oncology research and data sharing. Exceptional Longevity Data Management and Coordinating Center, design and perform cross-project analysis focused on harnessing systems biology-based techniques, such as multi-omic data integration, network analysis, machine learning, and statistical modeling, to investigate both aging and disease, as well as the interplay between them.

• PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  $361,086

  2022 · SPONSORED RESEARCH SUB-AWARD

• SEATTLE CHILDRENS HOSPITAL

  $349,566

  2022 · PEDIATRIC MEDICAL RESEARCH GRANT SUBAWARD

• CORNELL UNIVERSITY

  $343,541

  2022 · Research

• EVERY CURE INC

  $309,022

  2024 · ISB WILL CURATE, EVALUATE, AND INTEGRATE LARGE BIOMEDICAL DATASETS INTO EVERY CURE'S KNOWLEDGE GRAPH, FOCUSING ON DATA QUALITY AND ONTOLOGY HARMONIZATION. THEY WILL PERFORM MANUAL CURATION, CROSS-VALIDATION, AND DEVELOPMENT OF PROTOCOLS TO ENSURE RELIABLE DRUG, DISEASE, AND MOLECULAR ASSOCIATIONS. THEIR WORK ENSURES THE SPOKE DATABASE AND OTHER KEY SOURCES ARE INCORPORATED INTO A ROBUST COMPUTATIONAL FRAMEWORK FOR DRUG REPURPOSING.

The 10 largest by cash amount. The API serves every itemized grant.

Related organizations

From Schedule R Part II, where a filer lists the tax-exempt organizations it is related to by control. It does not record shared board members or money.

Taxable family

From Schedule R Parts I, III and IV: entities that legally are the filer, and taxable partnerships, corporations and trusts it is related to. These record ownership and control, not shared board members or money.

Other IRS files